Literature DB >> 7622252

Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.

D Figueiredo1, C Turcotte, G Frankel, Y Li, O Dolly, G Wilkin, D Marriott, N Fairweather, G Dougan.   

Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

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Year:  1995        PMID： 7622252      PMCID： PMC173441          DOI： 10.1128/iai.63.8.3218-3221.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

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Authors:  M Pizza; A Covacci; A Bartoloni; M Perugini; L Nencioni; M T De Magistris; L Villa; D Nucci; R Manetti; M Bugnoli
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

2.  The complete nucleotide sequence of tetanus toxin.

Authors:  N F Fairweather; V A Lyness
Journal:  Nucleic Acids Res       Date:  1986-10-10       Impact factor: 16.971

3.  Antibodies against the light chain of tetanus toxin in human sera.

Authors:  C S Lin; W H Habig; M C Hardegree
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4.  Structure of tetanus toxin. II. Toxin binding to ganglioside.

Authors:  T B Helting; O Zwisler; H Wiegandt
Journal:  J Biol Chem       Date:  1977-01-10       Impact factor: 5.157

5.  Isolation and characterization of Corynebacterium diphtheriae nontandem double lysogens hyperproducing CRM197.

Authors:  R Rappuoli
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6.  Immunization of mice against tetanus with fragments of tetanus toxin synthesized in Escherichia coli.

Authors:  N F Fairweather; V A Lyness; D J Maskell
Journal:  Infect Immun       Date:  1987-11       Impact factor: 3.441

7.  Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier.

Authors:  N F Fairweather; S N Chatfield; A J Makoff; R A Strugnell; J Bester; D J Maskell; G Dougan
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8.  Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver.

Authors:  P W Angus; G W Mihaly; D J Morgan; R A Smallwood
Journal:  J Pharmacol Exp Ther       Date:  1989-09       Impact factor: 4.030

9.  A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.

Authors:  Y Li; P Foran; N F Fairweather; A de Paiva; U Weller; G Dougan; J O Dolly
Journal:  Biochemistry       Date:  1994-06-07       Impact factor: 3.162

10.  Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.

Authors:  U Eisel; W Jarausch; K Goretzki; A Henschen; J Engels; U Weller; M Hudel; E Habermann; H Niemann
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598
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  10 in total

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2.  Expression of tetanus toxin Fragment C in tobacco chloroplasts.

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Journal:  Nucleic Acids Res       Date:  2003-02-15       Impact factor: 16.971

3.  Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin.

Authors:  S Mesnage; M Weber-Levy; M Haustant; M Mock; A Fouet
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

4.  Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin.

Authors:  R Anderson; X M Gao; A Papakonstantinopoulou; M Roberts; G Dougan
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

5.  TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR.

Authors:  J C Marvaud; U Eisel; T Binz; H Niemann; M R Popoff
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

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Authors:  Patrícia A E Abreu; Patrícia A Miyasato; Mônica M Vilar; Waldely O Dias; Paulo L Ho; Míriam Tendler; Ana L T O Nascimento
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Review 7.  Receptor and substrate interactions of clostridial neurotoxins.

Authors:  Axel T Brunger; Andreas Rummel
Journal:  Toxicon       Date:  2009-03-04       Impact factor: 3.033

Review 8.  Tetanus toxin C-fragment: the courier and the cure?

Authors:  Janne M Toivonen; Sara Oliván; Rosario Osta
Journal:  Toxins (Basel)       Date:  2010-10-29       Impact factor: 4.546

9.  On-demand biomanufacturing of protective conjugate vaccines.

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Review 10.  Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy.

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  10 in total

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