Literature DB >> 7621851

Paracetamol disposition in Thai patients during and after treatment of falciparum malaria.

S Ismail1, K Na Bangchang, J Karbwang, D J Back, G Edwards.   

Abstract

Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria. We have measured plasma concentrations and the urinary excretion of paracetamol and its phase II metabolites in eight Thai patients during uncomplicated falciparum malaria and in convalescence, following a 1000 mg single oral dose. The apparent oral clearance (Malaria, 3.6; Convalescence, 3.9; ml.min-1.kg-1), the elimination half-life (Malaria, 3.8; Convalescence, 3.7 h) and apparent volume of distribution (Malaria, 1.2; Convalescence, 1.2; l.kg-1) of paracetamol were similar during malaria and convalescence. In addition, the urinary excretion of paracetamol and its major phase II metabolites and their formation clearances from paracetamol were not significantly different between the two study phases. These data show that clinical malaria infection has no effect on the conjugation of paracetamol in man.

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Year:  1995        PMID： 7621851     DOI： 10.1007/bf00202175

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  30 in total

1.  Paracetamol metabolism following overdosage: application of high performance liquid chromatography.

Authors:  D Howie; P I Adriaenssens; L F Prescott
Journal:  J Pharm Pharmacol       Date:  1977-04       Impact factor: 3.765

2.  Single dose primaquine has no effect on paracetamol clearance.

Authors:  D J Back; J F Tjia
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

3.  The metabolism of phenacetin in patients with enal diseas.

Authors:  L F Prescott
Journal:  Clin Pharmacol Ther       Date:  1969 May-Jun       Impact factor: 6.875

4.  Inter-subject and ethnic differences in paracetamol metabolism.

Authors:  J A Critchley; G R Nimmo; C A Gregson; N M Woolhouse; L F Prescott
Journal:  Br J Clin Pharmacol       Date:  1986-12       Impact factor: 4.335

5.  Influence of trivalent influenza vaccine on serum theophylline levels.

Authors:  R G Fischer; B H Booth; D Q Mitchell; A H Kibbe
Journal:  Can Med Assoc J       Date:  1982-06-01       Impact factor: 8.262

6.  Depression of aminopyrine metabolism by influenza vaccination.

Authors:  P Kramer; C J McClain
Journal:  N Engl J Med       Date:  1981-11-19       Impact factor: 91.245

7.  Quinine disposition during malaria and during induced fever.

Authors:  G M Trenholme; R L Williams; K H Rieckmann; H Frischer; P E Carson
Journal:  Clin Pharmacol Ther       Date:  1976-04       Impact factor: 6.875

8.  The effect of malaria infection on paracetamol disposition in the rat.

Authors:  S M Mansor; G Edwards; P J Roberts; S A Ward
Journal:  Biochem Pharmacol       Date:  1991-06-01       Impact factor: 5.858

9.  Studies of mefloquine bioavailability and kinetics using a stable isotope technique: a comparison of Thai patients with falciparum malaria and healthy Caucasian volunteers.

Authors:  S Looareesuwan; N J White; D A Warrell; I Forgo; U G Dubach; U B Ranalder; D E Schwartz
Journal:  Br J Clin Pharmacol       Date:  1987-07       Impact factor: 4.335

10.  The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes.

Authors:  S Ismail; D J Back; G Edwards
Journal:  Biochem Pharmacol       Date:  1992-11-03       Impact factor: 5.858
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  6 in total

Review 1.  Antipyretic measures for treating fever in malaria.

Authors:  Martin M Meremikwu; Chibuzo C Odigwe; Bridget Akudo Nwagbara; Ekong E Udoh
Journal:  Cochrane Database Syst Rev       Date:  2012-09-12

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Authors:  M Meremikwu; A Oyo-Ita
Journal:  Cochrane Database Syst Rev       Date:  2002

3.  Paracetamol and metabolite pharmacokinetics in infants.

Authors:  Caroline D van der Marel; Brian J Anderson; Richard A van Lingen; Nicholas H G Holford; Marien A L Pluim; Frank G A Jansman; John N van den Anker; Dick Tibboel
Journal:  Eur J Clin Pharmacol       Date:  2003-05-22       Impact factor: 2.953

4.  Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.

Authors:  Katherine Plewes; Hugh W F Kingston; Aniruddha Ghose; Thanaporn Wattanakul; Md Mahtab Uddin Hassan; Md Shafiul Haider; Prodip K Dutta; Md Akhterul Islam; Shamsul Alam; Selim Md Jahangir; A S M Zahed; Md Abdus Sattar; M A Hassan Chowdhury; M Trent Herdman; Stije J Leopold; Haruhiko Ishioka; Kim A Piera; Prakaykaew Charunwatthana; Kamolrat Silamut; Tsin W Yeo; Sue J Lee; Mavuto Mukaka; Richard J Maude; Gareth D H Turner; Md Abul Faiz; Joel Tarning; John A Oates; Nicholas M Anstey; Nicholas J White; Nicholas P J Day; Md Amir Hossain; L Jackson Roberts Ii; Arjen M Dondorp
Journal:  Clin Infect Dis       Date:  2018-09-14       Impact factor: 9.079

5.  Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.

Authors:  Thanaporn Wattanakul; Pramote Teerapong; Katherine Plewes; Paul N Newton; Wirongrong Chierakul; Kamolrat Silamut; Kesinee Chotivanich; Ronnatrai Ruengweerayut; Nicholas J White; Arjen M Dondorp; Joel Tarning
Journal:  Malar J       Date:  2016-04-27       Impact factor: 2.979

6.  The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial.

Authors:  Daniel J Cooper; Katherine Plewes; Matthew J Grigg; Giri S Rajahram; Kim A Piera; Timothy William; Mark D Chatfield; Tsin Wen Yeo; Arjen M Dondorp; Nicholas M Anstey; Bridget E Barber
Journal:  Trials       Date:  2018-04-24       Impact factor: 2.279
  6 in total

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