Literature DB >> 1449539

The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes.

S Ismail1, D J Back, G Edwards.   

Abstract

The effect of malaria infection on UDP-glucuronosyltransferase (UDPGT) activity was investigated in rat liver microsomes using 3'-azido-3'-deoxythymidine and paracetamol. The Michaelis-Menten parameters, Km and Vmax were calculated and intrinsic clearance values were estimated for normal and infected livers. The results show that malaria infection alters the activity of UDPGT.

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Year:  1992        PMID： 1449539     DOI： 10.1016/0006-2952(92)90084-v

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  2 in total

1.  Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.

Authors:  Elke H J Krekels; Marie Angesjö; Ingemo Sjögren; Kristina Angeby Möller; Odd-Geir Berge; Sandra A G Visser
Journal:  Pharm Res       Date:  2011-02-23       Impact factor: 4.200

2.  Paracetamol disposition in Thai patients during and after treatment of falciparum malaria.

Authors:  S Ismail; K Na Bangchang; J Karbwang; D J Back; G Edwards
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953
  2 in total

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