Literature DB >> 7620976

RNA viruses as vectors for the expression of heterologous proteins.

S Schlesinger1.   

Abstract

RNA viruses comprise a wide variety of infectious agents, some of which are the cause of disease in humans, animals, and plants. Recombinant DNA technology is now making it feasible to modify these genomes and engineer them to express heterologous proteins. Several different schemes are being employed that depend on the genome organization of the virus and on the strategy of replication of the particular virus. Several different examples are illustrated and potential uses as well as possible problems are discussed. In the future reverse genetics may convert some of these viruses from agents of disease to agents of cure.

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Year:  1995        PMID： 7620976     DOI： 10.1007/BF02789111

Source DB:  PubMed          Journal:  Mol Biotechnol        ISSN： 1073-6085            Impact factor:   2.695


  33 in total

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Authors:  K H Park; T Huang; F F Correia; M Krystal
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

2.  Rescue of synthetic analogs of respiratory syncytial virus genomic RNA and effect of truncations and mutations on the expression of a foreign reporter gene.

Authors:  P L Collins; M A Mink; D S Stec
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

3.  Will transgenic crops generate new viruses and new diseases?

Authors:  B W Falk; G Bruening
Journal:  Science       Date:  1994-03-11       Impact factor: 47.728

Review 4.  Inhibition of cell functions by RNA-virus infections.

Authors:  L Kääriäinen; M Ranki
Journal:  Annu Rev Microbiol       Date:  1984       Impact factor: 15.500

5.  A new generation of animal cell expression vectors based on the Semliki Forest virus replicon.

Authors:  P Liljeström; H Garoff
Journal:  Biotechnology (N Y)       Date:  1991-12

6.  Sindbis virus: an efficient, broad host range vector for gene expression in animal cells.

Authors:  C Xiong; R Levis; P Shen; S Schlesinger; C M Rice; H V Huang
Journal:  Science       Date:  1989-03-03       Impact factor: 47.728

7.  Recombination between viral RNA and transgenic plant transcripts.

Authors:  A E Greene; R F Allison
Journal:  Science       Date:  1994-03-11       Impact factor: 47.728

8.  Tagging of plant potyvirus replication and movement by insertion of beta-glucuronidase into the viral polyprotein.

Authors:  V V Dolja; H J McBride; J C Carrington
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

9.  Infectious defective interfering particles of VSV from transcripts of a cDNA clone.

Authors:  A K Pattnaik; L A Ball; A W LeGrone; G W Wertz
Journal:  Cell       Date:  1992-06-12       Impact factor: 41.582

Review 10.  Alphaviruses--vectors for the expression of heterologous genes.

Authors:  S Schlesinger
Journal:  Trends Biotechnol       Date:  1993-01       Impact factor: 19.536
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  6 in total

1.  Identification of 5' and 3' cis-acting elements of the porcine reproductive and respiratory syndrome virus: acquisition of novel 5' AU-rich sequences restored replication of a 5'-proximal 7-nucleotide deletion mutant.

Authors:  Yu-Jeong Choi; Sang-Im Yun; Shien-Young Kang; Young-Min Lee
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

2.  Analysis of a recombinant mouse hepatitis virus expressing a foreign gene reveals a novel aspect of coronavirus transcription.

Authors:  F Fischer; C F Stegen; C A Koetzner; P S Masters
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

3.  Efficient expression by an alphavirus replicon of a functional ribozyme targeted to human immunodeficiency virus type 1.

Authors:  S M Smith; F Maldarelli; K T Jeang
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

4.  Regulated expression of a Sindbis virus replicon by herpesvirus promoters.

Authors:  L Ivanova; S Schlesinger; P D Olivo
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

5.  Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames.

Authors:  S Mueller; E Wimmer
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

Review 6.  Comparison of the replication of positive-stranded RNA viruses of plants and animals.

Authors:  K W Buck
Journal:  Adv Virus Res       Date:  1996       Impact factor: 9.937
  6 in total

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