Literature DB >> 761489

Distribution of spontaneous chromosome breaks in man.

M G Mattei, S Ayme, J F Mattei, Y Aurran, F Giraud.   

Abstract

The distribution of break points in human chromosomes was analyzed in 15,754 metaphases from 1084 patients. A total of 1099 breaks were specifically localized to a chromosome band or region depicted in the PARIS CONFERENCE (1971) report. The sites of the breaks were very different from the expected random distribution and showed distinct clustering of breaks in some regions. These observations underline the heterogeneity of chromosomal material and furnish comparative data for the study of cytotoxic agents and constitutional chromosomal fragility.

Entities:  

Mesh：

Year:  1979        PMID： 761489     DOI： 10.1159/000131309

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  18 in total

1.  Acquired chromosome rearrangements in human lymphocytes: effect of aging.

Authors:  M Prieur; W Al Achkar; A Aurias; J Couturier; A M Dutrillaux; B Dutrillaux; A Flüry-Herard; M Gerbault-Seureau; F Hoffschir; E Lamoliatte
Journal:  Hum Genet       Date:  1988-06       Impact factor: 4.132

2.  The rate of chromosome breakage is age dependent in lymphocytes of adult controls.

Authors:  F Marlhens; W A Achkar; A Aurias; J Couturier; A M Dutrillaux; M Gerbault-Sereau; F Hoffschir; E Lamoliatte; D Lefrançois; M Lombard
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132

3.  Non-random in vitro 7;14 translocations detected in a routine cytogenetic series. 12 examples and their possible significance.

Authors:  C Wallace; R Bernstein; M R Pinto
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  Non-specific X-linked mental retardation with fragile X chromosome: somatic features, cytogenetic diagnosis and elements for genetic counselling.

Authors:  M A de Arce; E Law; J G Masterson
Journal:  Ir J Med Sci       Date:  1983-12       Impact factor: 1.568

5.  Analysis of a break in chromosome 14 mapping to the region of the immunoglobulin heavy chain locus.

Authors:  P S Linsley; N T Bech-Hansen; L Siminovitch; D W Cox
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

Review 6.  The current state of research with peripheral tissues in Huntington disease.

Authors:  G C Beverstock
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Highly polymorphic DNA site D14S1 maps to the region of Burkitt lymphoma translocation and is closely linked to the heavy chain gamma 1 immunoglobulin locus.

Authors:  I Balazs; M Purrello; P Rubinstein; B Alhadeff; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

8.  IgG heavy chain allotype (Gm), a genetic marker for human chromosome 14q32, and haematopoietic malignancies.

Authors:  Y Nakao; H Matsumoto; K Tsuji; T Miyazaki; T Masaoka; S Nakayama; K Kinoshita; T Shingami; T Matsui; T Fujita
Journal:  Clin Exp Immunol       Date:  1984-06       Impact factor: 4.330

9.  Human chromosome hot points. 1. Hot point at 3p14 in three populations.

Authors:  X T Zhou; B H Xu; C L Chu; G F Xia; N Li; R Sha
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

Review 10.  The fragile X syndrome: the patients and their chromosomes.

Authors:  M A De Arce; A Kearns
Journal:  J Med Genet       Date:  1984-04       Impact factor: 6.318
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