Literature DB >> 7613089

The Escherichia coli RNA polymerase alpha subunit: structure and function.

R H Ebright1, S Busby.   

Abstract

Recent work has established that the Escherichia coli RNA polymerase alpha subunit consists of an amino-terminal domain containing determinants for interaction with the remainder of RNA polymerase, a carboxy-terminal domain containing determinants for interaction with DNA and interaction with transcriptional activator proteins, and a 13-36 amino acid unstructured and/or flexible linker. These findings suggest a simple, integrated model for the mechanism of involvement of alpha in promoter recognition and transcriptional activation.

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Year:  1995        PMID： 7613089     DOI： 10.1016/0959-437x(95)80008-5

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  53 in total

1.  Mechanism of repression of the aroP P2 promoter by the TyrR protein of Escherichia coli.

Authors:  J Yang; P Wang; A J Pittard
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria.

Authors:  Q Tan; K L Linask; R H Ebright; N A Woychik
Journal:  Genes Dev       Date:  2000-02-01       Impact factor: 11.361

3.  Genetic evidence that transcription activation by RhaS involves specific amino acid contacts with sigma 70.

Authors:  P M Bhende; S M Egan
Journal:  J Bacteriol       Date:  2000-09       Impact factor: 3.490

4.  Coactivation of the RpoS-dependent proP P2 promoter by fis and cyclic AMP receptor protein.

Authors:  S M McLeod; J Xu; R C Johnson
Journal:  J Bacteriol       Date:  2000-08       Impact factor: 3.490

5.  Role of the RNA polymerase alpha subunits in MetR-dependent activation of metE and metH: important residues in the C-terminal domain and orientation requirements within RNA polymerase.

Authors:  P S Fritsch; M L Urbanowski; G V Stauffer
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

6.  Transcription activation by phage phi29 protein p4 is mediated by interaction with the alpha subunit of Bacillus subtilis RNA polymerase.

Authors:  M Mencía; M Monsalve; F Rojo; M Salas
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

7.  Positioning of two alpha subunit carboxy-terminal domains of RNA polymerase at promoters by two transcription factors.

Authors:  K Murakami; J T Owens; T A Belyaeva; C F Meares; S J Busby; A Ishihama
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

8.  Association of RNA polymerase with transcribed regions in Escherichia coli.

Authors:  Joseph T Wade; Kevin Struhl
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-13       Impact factor: 11.205

9.  Proteomic studies of an Antarctic cold-adapted bacterium, Shewanella livingstonensis Ac10, for global identification of cold-inducible proteins.

Authors:  Jun Kawamoto; Tatsuo Kurihara; Masanari Kitagawa; Ikunoshin Kato; Nobuyoshi Esaki
Journal:  Extremophiles       Date:  2007-07-07       Impact factor: 2.395

10.  Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase alpha subunit.

Authors:  N J Savery; G S Lloyd; M Kainz; T Gaal; W Ross; R H Ebright; R L Gourse; S J Busby
Journal:  EMBO J       Date:  1998-06-15       Impact factor: 11.598
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