Literature DB >> 7612161

Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2. A new animal model of schizophrenia?

P M Whitaker-Azmitia1, A Borella, N Raio.   

Abstract

Many trophic factors are now thought to also function in maintenance of the adult brain. We hypothesized that since serotonin plays a role in synaptogenesis, it may also function in maintenance of synapses in the adult. Adult rats were depleted of serotonin with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA) for 10 days. Fourteen days after the final treatment, immunodensitometry showed a significant decrease in the synaptic marker, MAP-2. Our results are discussed in respect to the recent finding of decreased MAP-2 staining in postmortem schizophrenic brains.

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Year:  1995        PMID： 7612161     DOI： 10.1016/0893-133X(94)00081-A

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  5 in total

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Journal:  Dev Neurosci       Date:  2013-08-27       Impact factor: 2.984

2.  Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.

Authors:  Rajapillai L I Pillai; Ashwin Malhotra; Deborah D Rupert; Bennett Weschler; John C Williams; Mengru Zhang; Jie Yang; J John Mann; Maria A Oquendo; Ramin V Parsey; Christine DeLorenzo
Journal:  Hum Brain Mapp       Date:  2017-11-27       Impact factor: 5.038

3.  Copy number variations of chromosome 16p13.1 region associated with schizophrenia.

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Journal:  Mol Psychiatry       Date:  2009-09-29       Impact factor: 15.992

4.  Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes.

Authors:  James Oluwagbamigbe Fajemiroye; José Luís Rodrigues Martins; Paulo César Ghedini; Pablinny Morreira Galdino; Joelma Abadia Marciano de Paula; José Realino de Paula; Fabio Fagundes Da Rocha; Elson Alves Costa
Journal:  Evid Based Complement Alternat Med       Date:  2013-01-09       Impact factor: 2.629

5.  Developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate, disrupts the mesocortical serotonin pathway and alters impulsive decision-making in rats.

Authors:  Allyssa Fahrenkopf; Grace Li; Ruth I Wood; Christine K Wagner
Journal:  Dev Neurobiol       Date:  2021-08-13       Impact factor: 3.102
  5 in total

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