Literature DB >> 7612005

Diabetes affects alpha-crystallin chaperone function.

M Cherian1, E C Abraham.   

Abstract

In vitro glycation was previously shown to influence alpha-crystallin chaperone function. In the present study we show that this function is compromised in diabetes. The alpha H, alpha L and the total alpha fractions were isolated by gel permeation chromatography from the water-soluble protein of streptozotocin-diabetic as well as age-matched normal rats. Based on the beta L-crystallin thermal denaturation assay the chaperone function was significantly decreased in the diabetic rats.

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Year:  1995        PMID： 7612005     DOI： 10.1006/bbrc.1995.1954

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirus.

Authors:  Y H Kim; S Y Park; J Park; Y S Kim; E M Hwang; J Y Park; G S Roh; H J Kim; S S Kang; G J Cho; W S Choi
Journal:  Diabetologia       Date:  2012-07-08       Impact factor: 10.122

2.  Increased levels of advanced glycation endproducts in the lenses and blood vessels of cigarette smokers.

Authors:  I D Nicholl; A W Stitt; J E Moore; A J Ritchie; D B Archer; R Bucala
Journal:  Mol Med       Date:  1998-09       Impact factor: 6.354

3.  Modulation of the chaperone-like activity of bovine alpha-crystallin.

Authors:  J I Clark; Q L Huang
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

4.  alpha-Crystallin chaperone function in diabetic rat and human lenses.

Authors:  Prajitha Thampi; Shamshad Zarina; Edathara C Abraham
Journal:  Mol Cell Biochem       Date:  2002-01       Impact factor: 3.396

5.  Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins.

Authors:  Edathara C Abraham; Jin Huaqian; Atya Aziz; Anbarasu Kumarasamy; Poppy Datta
Journal:  Mol Cell Biochem       Date:  2007-12-25       Impact factor: 3.396

6.  Reversal of chaperone activity loss of glycated alphaA-crystallin by a crosslink breaker.

Authors:  Poppy Datta; Latha Kallur; Edathara C Abraham
Journal:  Mol Cell Biochem       Date:  2008-06-03       Impact factor: 3.396

7.  Impact of diabetes on alpha-crystallins and other heat shock proteins in the eye.

Authors:  Erich A Heise; Patrice E Fort
Journal:  J Ocul Biol Dis Infor       Date:  2011-12-23

8.  Effect of glycation on alpha-crystallin structure and chaperone-like function.

Authors:  P Anil Kumar; M Satish Kumar; G Bhanuprakash Reddy
Journal:  Biochem J       Date:  2007-12-01       Impact factor: 3.857

9.  FoxO3a Serves as a Biomarker of Oxidative Stress in Human Lens Epithelial Cells under Conditions of Hyperglycemia.

Authors:  Ilangovan Raju; Krishnaswamy Kannan; Edathara C Abraham
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240

10.  Effect of curcumin on the modulation of αA- and αB-crystallin and heat shock protein 70 in selenium-induced cataractogenesis in Wistar rat pups.

Authors:  R Manikandan; M Beulaja; R Thiagarajan; M Arumugam
Journal:  Mol Vis       Date:  2011-02-04       Impact factor: 2.367
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