Literature DB >> 7609773

Evidence for the involvement of the 5-HT1A receptor in CCK induced satiety in rats.

J P Voigt1, H Fink, C A Marsden.   

Abstract

The present study was designed to examine possible interactions between exogenous CCK and the 5-HT1A receptor subtype mediated serotonergic effects on feeding in rats. The somatodendritic 5-HT1A receptor agonist 8-OH-DPAT (0.32 mg/kg sc) evoked feeding in freely feeding rats. This effect was attenuated by treatment with CCK-8 (1, 5 and 25 micrograms/kg ip). In food deprived rats, CCK-8 (40 micrograms/kg ip) significantly reduced the size of a test meal. Treatment with the 5-HT1A receptor antagonist WAY-100135 (10 mg/kg ip) antagonized this anorectic effect of CCK-8. WAY-100135 on its own did not affect food intake. These results suggest the involvement of the 5-HT1A receptor subtype in mediating 5-HT-CCK interactions in the control of food intake in rats.

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Year:  1995        PMID： 7609773     DOI： 10.1007/BF00233239

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  19 in total

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Authors:  C Routledge; J Gurling; I K Wright; C T Dourish
Journal:  Eur J Pharmacol       Date:  1993-08-03       Impact factor: 4.432

6.  8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons.

Authors:  C Bendotti; R Samanin
Journal:  Eur J Pharmacol       Date:  1986-02-11       Impact factor: 4.432

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Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

8.  Pharmacology of a cholecystokinin receptor on 5-hydroxytryptamine neurones in the dorsal raphe of the rat brain.

Authors:  P R Boden; G N Woodruff; R D Pinnock
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

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Authors:  P H Hutson; C T Dourish; G Curzon
Journal:  Eur J Pharmacol       Date:  1986-10-07       Impact factor: 4.432

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Authors:  P H Hutson; C T Dourish; G Curzon
Journal:  Eur J Pharmacol       Date:  1988-06-10       Impact factor: 4.432
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  3 in total

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Journal:  PLoS Genet       Date:  2014-09-04       Impact factor: 5.917

Review 3.  Central 5-HTR2C in the Control of Metabolic Homeostasis.

Authors:  Ting Yao; Jiehui He; Zhicheng Cui; Ruwen Wang; Kaixuan Bao; Yiru Huang; Ru Wang; Tiemin Liu
Journal:  Front Endocrinol (Lausanne)       Date:  2021-07-21       Impact factor: 5.555
  3 in total

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