Literature DB >> 2937644

8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons.

C Bendotti, R Samanin.   

Abstract

A subcutaneous injection of 0.5 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a drug with high affinity for 5-hydroxytryptamine (5-HT1A) binding sites, substantially increased eating in non-deprived rats. Intraventricular injections of 5,7-dihydroxytryptamine (5,7-DHT), a neurotoxin for 5-HT neurons, also significantly increased eating in rats and antagonized the effect of 8-OH-DPAT. Microinjections of 8-OH-DPAT (0.5 and 1 microgram) in the nuclei dorsalis and medianus raphe also significantly increased eating in rats. 8-OH-DPAT appears to stimulate eating by acting on 5-HT-containing neurons. These results are compatible with the hypothesis that a decrease in central 5-HT function disinhibits feeding.

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Year:  1986        PMID： 2937644     DOI： 10.1016/0014-2999(86)90405-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  28 in total

1.  Low doses of 8-OH-DPAT prevent the impairment of spatial learning caused by intrahippocampal scopolamine through 5-HT(1A) receptors in the dorsal raphe.

Authors:  M Carli; C Balducci; R Samanin
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

2.  Selective serotonin receptor stimulation of the medial nucleus accumbens differentially affects appetitive motivation for food on a progressive ratio schedule of reinforcement.

Authors:  Wayne E Pratt; Megan A Schall; Eugene Choi
Journal:  Neurosci Lett       Date:  2012-01-24       Impact factor: 3.046

3.  A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat.

Authors:  Wayne E Pratt; Kara A Clissold; Peagan Lin; Amanda E Cain; Alexa F Ciesinski; Thomas R Hopkins; Adeolu O Ilesanmi; Erin A Kelly; Zachary Pierce-Messick; Daniel S Powell; Ian A Rosner
Journal:  Brain Res       Date:  2016-07-16       Impact factor: 3.252

4.  8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition.

Authors:  J K Shepherd; R J Rodgers
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 5.  The role of serotonin in eating disorders.

Authors:  S F Leibowitz
Journal:  Drugs       Date:  1990       Impact factor: 9.546

6.  Influence of taste and food texture on the feeding responses induced by 8-OH-DPAT and gepirone.

Authors:  P J Fletcher; M H Zack; D V Coscina
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  Evidence for the involvement of the 5-HT1A receptor in CCK induced satiety in rats.

Authors:  J P Voigt; H Fink; C A Marsden
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-03       Impact factor: 3.000

Review 8.  A step towards developing the expertise to control hunger and satiety: regulatory role of satiomem--a membrane proteoglycan.

Authors:  R K Upreti; A M Kidwai
Journal:  Neurochem Res       Date:  1995-04       Impact factor: 3.996

9.  8-Hydroxy-2-(di-n-propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT1A receptors.

Authors:  M Carli; R Samanin
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

Review 10.  Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity.

Authors:  D McTavish; R C Heel
Journal:  Drugs       Date:  1992-05       Impact factor: 9.546
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