Literature DB >> 7609093

Downregulation of endothelin receptor mRNA synthesis in C6 rat astrocytoma cells by persistent measles virus and canine distemper virus infections.

N N Meissner1, K Koschel.   

Abstract

Persistent infections of C6 rat astrocytoma cells with measles (subacute sclerosing panencephalitis [SSPE]) virus (C6/SSPE cells) or canine distemper virus (C6/CDV cells) cause a loss of endothelin-1 (ET-1) binding to its specific receptors (ETRA type) and subsequent ET-1-induced Ca2+ signaling. It was the aim of this study to investigate the underlying mechanism of this phenomenon in more detail. By using an RNase protection assay, it was found that ETRA mRNA disappears, whereas other cellular mRNA species, e.g., beta-actin mRNA, were not influenced. The data show that the loss of the ET-1 signaling pathway in C6/SSPE and C6/CDV cells is due to a receptor downregulation at the transcriptional level.

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Year:  1995        PMID： 7609093      PMCID： PMC189344          DOI： 10.1128/JVI.69.8.5191-5194.1995

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

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4.  Brain tubulin and actin cDNA sequences: isolation of recombinant plasmids.

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5.  Visualization of defective measles virus particles in cerebrospinal fluid in subacute sclerosing panencephalitis.

Authors:  J Andersson; A Ehrnst; P H Larsson; K O Hedlund; E Norrby; R Nybom; M Forsgren; E Olding-Stenquist; B Persson
Journal:  J Infect Dis       Date:  1987-12       Impact factor: 5.226

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8.  Molecular cloning and expression in streptomyces lividans of a hygromycin B phosphotransferase gene from Streptomyces hygroscopicus.

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9.  The nucleotide sequence of the rat cytoplasmic beta-actin gene.

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  7 in total

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Journal:  J Neurovirol       Date:  2003-04       Impact factor: 2.643

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Review 5.  Measles virus interactions with cellular receptors: consequences for viral pathogenesis.

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Review 6.  Measles virus infection of the CNS: human disease, animal models, and approaches to therapy.

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7.  Human Cytomegalovirus Reduces Endothelin-1 Expression in Both Endothelial and Vascular Smooth Muscle Cells.

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Journal:  Microorganisms       Date:  2021-05-25
  7 in total

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