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Literature DB >> 7608142

Cyclin A links c-Myc to adhesion-independent cell proliferation.

J F Barrett¹, B C Lewis, A T Hoang, R J Alvarez, C V Dang.

Abstract

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

Entities: Gene Species

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Year: 1995 PMID： 7608142 DOI： 10.1074/jbc.270.27.15923

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

16 in total

1. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene.

Authors: B C Lewis; H Shim; Q Li; C S Wu; L A Lee; A Maity; C V Dang
Journal: Mol Cell Biol Date: 1997-09 Impact factor: 4.272

Review 2. Calcium, a Cell Cycle Commander, Drives Colon Cancer Cell Diffpoptosis.

Authors: Ahmed A Abd-Rabou
Journal: Indian J Clin Biochem Date: 2016-03-30

3. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events.

Authors: J S Kang; R S Krauss
Journal: Mol Cell Biol Date: 1996-07 Impact factor: 4.272

4. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.

Authors: Dai Horiuchi; Noelle E Huskey; Leonard Kusdra; Lara Wohlbold; Karl A Merrick; Chao Zhang; Katelyn J Creasman; Kevan M Shokat; Robert P Fisher; Andrei Goga
Journal: Proc Natl Acad Sci U S A Date: 2012-04-03 Impact factor: 11.205

5. Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.

Authors: J M Trowbridge; I Rogatsky; M J Garabedian
Journal: Proc Natl Acad Sci U S A Date: 1997-09-16 Impact factor: 11.205

6. Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.

Authors: Samuel McLenachan; Cristina Menchón; Angel Raya; Antonella Consiglio; Michael J Edel
Journal: Stem Cells Dev Date: 2012-06-25 Impact factor: 3.272

Cyclin A links c-Myc to adhesion-independent cell proliferation.

1. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene.

Review 2. Calcium, a Cell Cycle Commander, Drives Colon Cancer Cell Diffpoptosis.

3. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events.

4. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.

5. Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.

6. Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.

Review 7. Oncogenes in tumor metabolism, tumorigenesis, and apoptosis.

8. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis.

Review 9. MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies.

10. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.