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Literature DB >> 7604016

A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

Abstract

We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos is able to cause formation of a partial dorsal axis. These results suggest that XTrR-I encodes a receptor which responds in normal development to a transforming growth factor beta-like ligand so as to promote dorsalization. Its function would therefore be to direct mesodermalized tissue into muscle or notochord.

Entities: Gene Species

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Year: 1995 PMID： 7604016 PMCID： PMC41540 DOI： 10.1073/pnas.92.14.6474

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

43 in total

1. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.

Authors: P Lemaire; N Garrett; J B Gurdon
Journal: Cell Date: 1995-04-07 Impact factor: 41.582

2. Construction of subtracted cDNA libraries enriched for cDNAs for genes expressed in the mesoderm of early Xenopus gastrulae.

Authors: P Lemaire; N Garrett; K Kato; J B Gurdon
Journal: C R Acad Sci III Date: 1993-09

3. Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populations.

Authors: P D Henion; J A Weston
Journal: Dev Biol Date: 1994-01 Impact factor: 3.582

1. The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.

Authors: E Reissmann; H Jörnvall; A Blokzijl; O Andersson; C Chang; G Minchiotti; M G Persico; C F Ibáñez; A H Brivanlou
Journal: Genes Dev Date: 2001-08-01 Impact factor: 11.361

1 in total

A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

1. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.

2. Construction of subtracted cDNA libraries enriched for cDNAs for genes expressed in the mesoderm of early Xenopus gastrulae.

3. Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populations.

4. Biochemical specificity of Xenopus notochord.

5. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

6. Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes.

7. Cloning of a second type of activin receptor and functional characterization in Xenopus embryos.

8. The role of fibroblast growth factor in early Xenopus development.

9. Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.

10. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.

1. The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.