Literature DB >> 1313188

Cloning of a second type of activin receptor and functional characterization in Xenopus embryos.

L S Mathews1, W W Vale, C R Kintner.   

Abstract

A complementary DNA coding for a second type of activin receptor (ActRIIB) has been cloned from Xenopus laevis that fulfills the structural criteria of a transmembrane protein serine kinase. Ectodermal explants from embryos injected with activin receptor RNA show increased sensitivity to activin, as measured by the induction of muscle actin RNA. In addition, injected embryos display developmental defects characterized by inappropriate formation of dorsal mesodermal tissue. These results demonstrate that this receptor is involved in signal transduction and are consistent with the proposed role of activin in the induction and patterning of mesoderm in Xenopus embryos.

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Year:  1992        PMID： 1313188     DOI： 10.1126/science.1313188

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  41 in total

1.  A pair of transmembrane receptors essential for the retention and pigmentation of hair.

Authors:  Rong Han; Hideyuki Beppu; Yun-Kyoung Lee; Katia Georgopoulos; Lionel Larue; En Li; Lorin Weiner; Janice L Brissette
Journal:  Genesis       Date:  2012-06-19       Impact factor: 2.487

Review 2.  Paracrine factors and the regulation of spermatogenesis.

Authors:  C S Niederberger; S Shubhada; S J Kim; D J Lamb
Journal:  World J Urol       Date:  1993       Impact factor: 4.226

3.  Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.

Authors:  J J Lebrun; W W Vale
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

Review 4.  TGF-β Superfamily Regulation of Follicle-Stimulating Hormone Synthesis by Gonadotrope Cells: Is There a Role for Bone Morphogenetic Proteins?

Authors:  Luisina Ongaro; Gauthier Schang; Catherine C Ho; Xiang Zhou; Daniel J Bernard
Journal:  Endocrinology       Date:  2019-03-01       Impact factor: 4.736

5.  Cripto forms a complex with activin and type II activin receptors and can block activin signaling.

Authors:  Peter C Gray; Craig A Harrison; Wylie Vale
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

6.  Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression.

Authors:  Nedal Safwat; Jun Ninomiya-Tsuji; A Jesse Gore; William L Miller
Journal:  Endocrinology       Date:  2005-08-04       Impact factor: 4.736

Review 7.  Activins and Inhibins: Roles in Development, Physiology, and Disease.

Authors:  Maria Namwanje; Chester W Brown
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-07-01       Impact factor: 10.005

8.  Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

Authors:  B L Rosenzweig; T Imamura; T Okadome; G N Cox; H Yamashita; P ten Dijke; C H Heldin; K Miyazono
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm.

Authors:  A Bhushan; H Y Lin; H F Lodish; C R Kintner
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

10.  Activin betaA subunit, follistatin and follistatin-like 3 are expressed in the endometrium of ovariectomized rats and regulated by estrogen replacement.

Authors:  Márcia C Ferreira; Inês K D Cavallo; Pasquale Florio; Felice Petraglia; Fernando M Reis
Journal:  J Mol Histol       Date:  2008-09-09       Impact factor: 2.611
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