Literature DB >> 7601508

The antiinflammatory activity of topically applied novel calcium-channel antagonists.

G W De Vries1, A McLaughlin, M B Wenzel, J Perez, D Harcourt, G Lee, M Garst, L A Wheeler.   

Abstract

The antiinflammatory activities of two novel calcium-channel antagonists, AGN 190742 and AGN 190744, were evaluated in murine models of cutaneous inflammation. These 2(5H)-furanone ring compounds block both depolarization-dependent Ca2+ entry and receptor-mediated responses in GH3 cells. Topical application of AGN 190742 or AGN 190744 inhibits neutrophil infiltration and epidermal hyperplasia induced by repeated treatment of mouse skin with phorbol ester. AGN 190744 also is active in an arachidonic acid model of acute inflammation. These data suggest that topical application of calcium-channel antagonists can inhibit cutaneous inflammatory responses and that AGN 190742 and/or AGN 190744 may serve as useful pharmacological probes for examining these responses in vivo.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7601508     DOI： 10.1007/BF01534466

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  35 in total

1.  Inhibition by manoalide of fMLP-stimulated elastase release from human neutrophils.

Authors:  G W De Vries; L D Amdahl; K D Kramer; L A Wheeler
Journal:  Biochem Pharmacol       Date:  1990-12-01       Impact factor: 5.858

Review 2.  Receptor-mediated calcium entry.

Authors:  T J Rink
Journal:  FEBS Lett       Date:  1990-08-01       Impact factor: 4.124

3.  Calcium channel antagonist induced inhibition of superoxide production in human neutrophils. Mechanisms independent of antagonizing calcium influx.

Authors:  K Irita; I Fujita; K Takeshige; S Minakami; J Yoshitake
Journal:  Biochem Pharmacol       Date:  1986-10-15       Impact factor: 5.858

4.  Transcriptional modulation of human IL-6 gene expression by verapamil.

Authors:  G Walz; B Zanker; C Barth; K J Wieder; S C Clark; T B Strom
Journal:  J Immunol       Date:  1990-06-01       Impact factor: 5.422

5.  Effect of activation on adhesion of flowing neutrophils to cultured endothelium: time course and inhibition by a calcium channel blocker (nitrendipine).

Authors:  I Perry; S M Buttrum; G B Nash
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

6.  Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity.

Authors:  J Chang; E Blazek; R P Carlson
Journal:  Inflammation       Date:  1987-09       Impact factor: 4.092

7.  The effect of nifedipine on lipid and monocyte infiltration of the subendothelial space.

Authors:  J J Alexander; R Miguel; J J Piotrowski
Journal:  J Vasc Surg       Date:  1993-05       Impact factor: 4.268

8.  Inhibition of phosphoinositide-specific phospholipase C by manoalide.

Authors:  C F Bennett; S Mong; H L Wu; M A Clark; L Wheeler; S T Crooke
Journal:  Mol Pharmacol       Date:  1987-11       Impact factor: 4.436

9.  Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases.

Authors:  A M Mayer; K B Glaser; R S Jacobs
Journal:  J Pharmacol Exp Ther       Date:  1988-03       Impact factor: 4.030

10.  Nifedipine-induced hyporeactivity in delayed hypersensitivity skin tests.

Authors:  F Derenne; M Vanhaeverbeek; D Brohée
Journal:  Int J Immunopharmacol       Date:  1987
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.