| Literature DB >> 7600618 |
Y Takeuchi1, M Sunagawa, Y Isobe, Y Hamazume, T Noguchi.
Abstract
The stability and the degradation products of 1 beta-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution, pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1 beta-methyl group against hydrolysis of beta-lactam ring. As degradation products, the beta-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of beta-lactam ring by the amine of the second molecule were described.Entities:
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Year: 1995 PMID： 7600618 DOI： 10.1248/cpb.43.689
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645