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Literature DB >> 24900319

Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

Mark E Flanagan¹, Steven J Brickner², Manjinder Lall¹, Jeffrey Casavant¹, Laura Deschenes¹, Steven M Finegan¹, David M George¹, Karl Granskog¹, Joel R Hardink¹, Michael D Huband¹, Thuy Hoang¹, Lucinda Lamb¹, Andrea Marra³, Mark Mitton-Fry¹, John P Mueller¹, Lisa M Mullins¹, Mark C Noe¹, John P O'Donnell¹, David Pattavina¹, Joseph B Penzien¹, Brandon P Schuff¹, Jianmin Sun¹, David A Whipple⁴, Jennifer Young¹, Thomas D Gootz⁵.

Abstract

A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.

Entities: Chemical

Keywords: MC-1; Monocarbam; antibiotic; monobactam; siderophore-conjugate; β-lactam

Year: 2011 PMID： 24900319 PMCID： PMC4018130 DOI： 10.1021/ml200012f

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

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5. Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

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