Literature DB >> 7600562

Keyhole limpet hemocyanin contains Gal(beta 1-3)-GalNAc determinants that are cross-reactive with the T antigen.

I Wirguin1, L Suturkova-Milosević, C Briani, N Latov.   

Abstract

Keyhole limpet hemocyanin (KLH) is widely used as a carrier molecule to enhance immune responses to administered antigens, and for immunotherapy of bladder and renal carcinoma. In the present study we show, using lectin and antibody binding studies, that native KLH contains Gal(beta 1-3)GalNAc-bearing oligosaccharides, and that immunization with KLH in Lewis rats induces the production of anti-Gal(beta 1-3) GalNAc antibodies. This might explain the beneficial effect of KLH in bladder cancers that express cross-reactive Gal(beta 1-3)GalNAc determinants or the T antigen.

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Year:  1995        PMID： 7600562     DOI： 10.1007/BF01519630

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  15 in total

Review 1.  Immunotherapeutic alternatives in superficial bladder cancer. Interferon, interleukin-2, and keyhole-limpet hemocyanin.

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Journal:  J Immunother (1991)       Date:  1992-05

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Authors:  N C Langkilde; H Wolf; H Clausen; T Kjeldsen; T F Orntoft
Journal:  Cancer       Date:  1992-01-01       Impact factor: 6.860

4.  Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation.

Authors:  M P Woodward; W W Young; R A Bloodgood
Journal:  J Immunol Methods       Date:  1985-04-08       Impact factor: 2.303

5.  T cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: stimulation of anticancer T cell immunity in vivo.

Authors:  C M Henningsson; S Selvaraj; G D MacLean; M R Suresh; A A Noujaim; B M Longenecker
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

Review 6.  Gangliosides: structure, isolation, and analysis.

Authors:  R W Ledeen; R K Yu
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

7.  Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate.

Authors:  P Y Fung; M Madej; R R Koganty; B M Longenecker
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Authors:  F P Thomas; W Trojaborg; C Nagy; M Santoro; S A Sadiq; N Latov; A P Hays
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9.  GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines.

Authors:  F Helling; A Shang; M Calves; S Zhang; S Ren; R K Yu; H F Oettgen; P O Livingston
Journal:  Cancer Res       Date:  1994-01-01       Impact factor: 12.701

10.  Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice.

Authors:  A Singhal; M Fohn; S Hakomori
Journal:  Cancer Res       Date:  1991-03-01       Impact factor: 12.701
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  18 in total

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Review 3.  Transient immunosuppression: a bridge between infection and the atypical autoimmunity of Guillain-Barré syndrome?

Authors:  I Steiner; G Rosenberg; I Wirguin
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4.  Evaluation of human antibody responses to keyhole limpet hemocyanin on a carbohydrate microarray.

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Journal:  Proteomics Clin Appl       Date:  2010-02-11       Impact factor: 3.494

5.  A novel synthetic bipartite carrier protein for developing glycotope-based vaccines.

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Journal:  Vaccine       Date:  2012-10-22       Impact factor: 3.641

6.  Reactive immunization suppresses advanced glycation and mitigates diabetic nephropathy.

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Journal:  J Am Soc Nephrol       Date:  2009-04-23       Impact factor: 10.121

7.  Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages.

Authors:  Ta-Ying Zhong; Sergio Arancibia; Raimundo Born; Ricardo Tampe; Javiera Villar; Miguel Del Campo; Augusto Manubens; María Inés Becker
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8.  Abalone Hemocyanin Blocks the Entry of Herpes Simplex Virus 1 into Cells: a Potential New Antiviral Strategy.

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Journal:  Antimicrob Agents Chemother       Date:  2015-12-07       Impact factor: 5.191

9.  A novel Gal(beta1-4)Gal(beta1-4)Fuc(alpha1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans.

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10.  In vitro effect of molluscan hemocyanins on CAL-29 and T-24 bladder cancer cell lines.

Authors:  Olga Boyanova; Pavlina Dolashka; Draga Toncheva; Hans-Georg Rammensee; Stefan Stevanović
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