| Literature DB >> 760017 |
J Mendelson, J Portnoy, J R De Saint Victor, M M Gelfand.
Abstract
The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.Entities:
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Year: 1979 PMID： 760017
Source DB: PubMed Journal: Obstet Gynecol ISSN： 0029-7844 Impact factor: 7.661