Literature DB >> 7596812

Compact structures of d(CNG)n oligonucleotides in solution and their possible relevance to fragile X and related human genetic diseases.

J E Mitchell1, S F Newbury, J A McClellan.   

Abstract

We show that oligonucleotides of CNG tracts readily adopt compact DNA structures that move unusually fast on gels. Base composition does not explain this, and non-CNG triplets (including GNC) do not form such structures. Chemical probing and melting experiments suggest that the structures probably are not hairpins. Although both long and short tracts can adopt compact structures, the structure formed by longer tracts is more compact than that formed by shorter ones. We note the possibility that such structures may form in vivo, and be instrumental in normal and/or abnormal function of human genes.

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Year:  1995        PMID： 7596812      PMCID： PMC306957          DOI： 10.1093/nar/23.11.1876

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  33 in total

1.  Molecular and thermodynamic properties of d(A(+)-G)10, a single-stranded nucleic acid helix without paired or stacked bases.

Authors:  N G Dolinnaya; E H Braswell; J A Fossella; H Klump; J R Fresco
Journal:  Biochemistry       Date:  1993-09-28       Impact factor: 3.162

2.  Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism.

Authors:  H Green
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

3.  Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene.

Authors:  Y H Wang; S Amirhaeri; S Kang; R D Wells; J D Griffith
Journal:  Science       Date:  1994-07-29       Impact factor: 47.728

4.  The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

Authors:  M Fry; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

5.  Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation.

Authors:  S J Knight; A V Flannery; M C Hirst; L Campbell; Z Christodoulou; S R Phelps; J Pointon; H R Middleton-Price; A Barnicoat; M E Pembrey
Journal:  Cell       Date:  1993-07-16       Impact factor: 41.582

Review 6.  Hypermethylation of telomere-like foldbacks at codon 12 of the human c-Ha-ras gene and the trinucleotide repeat of the FMR-1 gene of fragile X.

Authors:  S S Smith; A Laayoun; R G Lingeman; D J Baker; J Riley
Journal:  J Mol Biol       Date:  1994-10-21       Impact factor: 5.469

7.  Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA).

Authors:  R Koide; T Ikeuchi; O Onodera; H Tanaka; S Igarashi; K Endo; H Takahashi; R Kondo; A Ishikawa; T Hayashi
Journal:  Nat Genet       Date:  1994-01       Impact factor: 38.330

8.  Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p.

Authors:  S Nagafuchi; H Yanagisawa; K Sato; T Shirayama; E Ohsaki; M Bundo; T Takeda; K Tadokoro; I Kondo; N Murayama
Journal:  Nat Genet       Date:  1994-01       Impact factor: 38.330

9.  Fragile X syndrome unstable element, p(CCG)n, and other simple tandem repeat sequences are binding sites for specific nuclear proteins.

Authors:  R I Richards; K Holman; S Yu; G R Sutherland
Journal:  Hum Mol Genet       Date:  1993-09       Impact factor: 6.150

10.  Characterization and localization of the FMR-1 gene product associated with fragile X syndrome.

Authors:  C Verheij; C E Bakker; E de Graaff; J Keulemans; R Willemsen; A J Verkerk; H Galjaard; A J Reuser; A T Hoogeveen; B A Oostra
Journal:  Nature       Date:  1993-06-24       Impact factor: 49.962
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  10 in total

Review 1.  Replication fork stalling at natural impediments.

Authors:  Ekaterina V Mirkin; Sergei M Mirkin
Journal:  Microbiol Mol Biol Rev       Date:  2007-03       Impact factor: 11.056

2.  Modelling studies on neurodegenerative disease-causing triplet repeat sequences d(GGC/GCC)n and d(CAG/CTG)n.

Authors:  S Chowdhury; M Bansal
Journal:  J Biosci       Date:  2001-12       Impact factor: 1.826

3.  Cloned human FMR1 trinucleotide repeats exhibit a length- and orientation-dependent instability suggestive of in vivo lagging strand secondary structure.

Authors:  M C Hirst; P J White
Journal:  Nucleic Acids Res       Date:  1998-05-15       Impact factor: 16.971

4.  NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases.

Authors:  K Usdin
Journal:  Nucleic Acids Res       Date:  1998-09-01       Impact factor: 16.971

5.  Context dependence of trinucleotide repeat structures.

Authors:  Natalya N Degtyareva; Courtney A Barber; Bidisha Sengupta; Jeffrey T Petty
Journal:  Biochemistry       Date:  2010-04-13       Impact factor: 3.162

6.  Conformational properties of DNA dodecamers containing four tandem repeats of the CNG triplets.

Authors:  M Vorlícková; M Zimulová; J Kovanda; P Fojtík; J Kypr
Journal:  Nucleic Acids Res       Date:  1998-06-01       Impact factor: 16.971

7.  The fragile X chromosome (GCC) repeat folds into a DNA tetraplex at neutral pH.

Authors:  P Fojtík; M Vorlícková
Journal:  Nucleic Acids Res       Date:  2001-11-15       Impact factor: 16.971

Review 8.  Trinucleotide repeats associated with human disease.

Authors:  M Mitas
Journal:  Nucleic Acids Res       Date:  1997-06-15       Impact factor: 16.971

9.  Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats.

Authors:  Samir Amrane; Barbara Saccà; Martin Mills; Madhu Chauhan; Horst H Klump; Jean-Louis Mergny
Journal:  Nucleic Acids Res       Date:  2005-07-21       Impact factor: 16.971

10.  Structural polymorphism exhibited by a quasipalindrome present in the locus control region (LCR) of the human beta-globin gene cluster.

Authors:  Mahima Kaushik; Shrikant Kukreti
Journal:  Nucleic Acids Res       Date:  2006-07-19       Impact factor: 16.971
  10 in total

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