Literature DB >> 7595598

Toxicity of sulphur-containing compounds to neuronal cell lines.

A R Pean1, R B Parsons, R H Waring, A C Williams, D B Ramsden.   

Abstract

Cysteine and its metabolites cysteine sulphinic acid (CSA) and taurine (TA) were shown to be toxic to human and rat neuronal cell lines. However, the mechanisms of action of CSA and TA appeared to be different. As MND/ALS patients have high plasma and CSF cysteine levels, they may have increased levels of neurotoxins in vivo, since cysteine was more toxic than CSA in the assay system used. Cysteic acid, homocysteic acid, BMAA and BOAA were also toxic to the cell lines used.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7595598     DOI： 10.1016/0022-510x(95)00078-g

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  8 in total

1.  Spectroscopic and Computational Investigation of the H155A Variant of Cysteine Dioxygenase: Geometric and Electronic Consequences of a Third-Sphere Amino Acid Substitution.

Authors:  Elizabeth J Blaesi; Brian G Fox; Thomas C Brunold
Journal:  Biochemistry       Date:  2015-05-01       Impact factor: 3.162

2.  Spectroscopic and computational characterization of substrate-bound mouse cysteine dioxygenase: nature of the ferrous and ferric cysteine adducts and mechanistic implications.

Authors:  Jessica D Gardner; Brad S Pierce; Brian G Fox; Thomas C Brunold
Journal:  Biochemistry       Date:  2010-07-27       Impact factor: 3.162

3.  Spectroscopic and computational characterization of the NO adduct of substrate-bound Fe(II) cysteine dioxygenase: insights into the mechanism of O2 activation.

Authors:  Elizabeth J Blaesi; Jessica D Gardner; Brian G Fox; Thomas C Brunold
Journal:  Biochemistry       Date:  2013-08-23       Impact factor: 3.162

4.  Synthesis, X-ray Structures, Electronic Properties, and O2/NO Reactivities of Thiol Dioxygenase Active-Site Models.

Authors:  Anne A Fischer; Nuru Stracey; Sergey V Lindeman; Thomas C Brunold; Adam T Fiedler
Journal:  Inorg Chem       Date:  2016-11-01       Impact factor: 5.165

5.  Sulfide Oxidation by O2: Synthesis, Structure and Reactivity of Novel Sulfide-Incorporated Fe(II) Bis(imino)pyridine Complexes.

Authors:  Leland R Widger; Maxime A Siegler; David P Goldberg
Journal:  Polyhedron       Date:  2013-07-13       Impact factor: 3.052

6.  Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit.

Authors:  Shamchal Bakavayev; Nimrod Chetrit; Tatiana Zvagelsky; Rasha Mansour; Maria Vyazmensky; Zeev Barak; Adrian Israelson; Stanislav Engel
Journal:  Sci Rep       Date:  2019-07-25       Impact factor: 4.379

7.  Ultra-pure single wall carbon nanotube fibres continuously spun without promoter.

Authors:  Catharina Paukner; Krzysztof K K Koziol
Journal:  Sci Rep       Date:  2014-02-04       Impact factor: 4.379

8.  Spectroscopic and computational investigation of iron(III) cysteine dioxygenase: implications for the nature of the putative superoxo-Fe(III) intermediate.

Authors:  Elizabeth J Blaesi; Brian G Fox; Thomas C Brunold
Journal:  Biochemistry       Date:  2014-08-29       Impact factor: 3.162
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.