Literature DB >> 7592454

Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.

S L Otten1, X Liu, J Ferguson, C R Hutchinson.   

Abstract

The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and gene disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinone.

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Year:  1995        PMID: 7592454      PMCID: PMC177529          DOI: 10.1128/jb.177.22.6688-6692.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN: 0021-9193            Impact factor:   3.490


  36 in total

1.  Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli.

Authors:  K Madduri; F Torti; A L Colombo; C R Hutchinson
Journal:  J Bacteriol       Date:  1993-06       Impact factor: 3.490

2.  Characterization of an IS-like element from Mycobacterium tuberculosis.

Authors:  F Mariani; E Piccolella; V Colizzi; R Rappuoli; R Gross
Journal:  J Gen Microbiol       Date:  1993-08

3.  Identification and sequence analysis of IS6501, an insertion sequence in Brucella spp.: relationship between genomic structure and the number of IS6501 copies.

Authors:  S Ouahrani; S Michaux; J Sri Widada; G Bourg; R Tournebize; M Ramuz; J P Liautard
Journal:  J Gen Microbiol       Date:  1993-12

4.  CDP-6-deoxy-delta 3,4-glucoseen reductase from Yersinia pseudotuberculosis: enzyme purification and characterization of the cloned gene.

Authors:  S F Lo; V P Miller; Y Lei; J S Thorson; H W Liu; J L Schottel
Journal:  J Bacteriol       Date:  1994-01       Impact factor: 3.490

Review 5.  Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

Authors:  H W Liu; J S Thorson
Journal:  Annu Rev Microbiol       Date:  1994       Impact factor: 15.500

6.  Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.

Authors:  A Grimm; K Madduri; A Ali; C R Hutchinson
Journal:  Gene       Date:  1994-12-30       Impact factor: 3.688

7.  Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.

Authors:  M L Dickens; J Ye; W R Strohl
Journal:  J Bacteriol       Date:  1995-02       Impact factor: 3.490

8.  Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation.

Authors:  C Hernández; C Olano; C Méndez; J A Salas
Journal:  Gene       Date:  1993-11-30       Impact factor: 3.688

9.  Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus.

Authors:  S L Otten; J Ferguson; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

10.  Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius.

Authors:  K Madduri; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

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  20 in total

1.  RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site.

Authors:  Celeste N Peterson; Natividad Ruiz; Thomas J Silhavy
Journal:  J Bacteriol       Date:  2004-11       Impact factor: 3.490

2.  The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production.

Authors:  N Lomovskaya; S K Hong; S U Kim; L Fonstein; K Furuya; R C Hutchinson
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

3.  Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.

Authors:  M L Dickens; J Ye; W R Strohl
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

4.  Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine.

Authors:  S L Otten; M A Gallo; K Madduri; X Liu; C R Hutchinson
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

5.  Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.

Authors:  Leandro M Garrido; Felipe Lombó; Irfan Baig; Mohammad Nur-E-Alam; Renata L A Furlan; Charlotte C Borda; Alfredo Braña; Carmen Méndez; José A Salas; Jürgen Rohr; Gabriel Padilla
Journal:  Appl Microbiol Biotechnol       Date:  2006-06-30       Impact factor: 4.813

6.  Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.

Authors:  Ah Reum Han; Je Won Park; Mi Kyeong Lee; Yeon Hee Ban; Young Ji Yoo; Eun Ji Kim; Eunji Kim; Byung-Gee Kim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Appl Environ Microbiol       Date:  2011-05-20       Impact factor: 4.792

7.  Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

Authors:  I Aguirrezabalaga; C Olano; N Allende; L Rodriguez; A F Braña; C Méndez; J A Salas
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

Review 8.  Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

Authors:  Jeffrey D Rudolf; Chin-Yuan Chang; Ming Ma; Ben Shen
Journal:  Nat Prod Rep       Date:  2017-08-30       Impact factor: 13.423

9.  Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis.

Authors:  K S Vetrivel; K Dharmalingam
Journal:  J Genet       Date:  2001-04       Impact factor: 1.166

10.  Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification.

Authors:  Katelyn V Brown; Benjamin Nji Wandi; Mikko Metsä-Ketelä; S Eric Nybo
Journal:  J Org Chem       Date:  2020-09-22       Impact factor: 4.354

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