Literature DB >> 9209071

Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine.

S L Otten1, M A Gallo, K Madduri, X Liu, C R Hutchinson.   

Abstract

Characterization of the dnmZ, dnmU, and dnmV genes from the daunorubicin-producer Streptomyces peucetius by DNA sequence analysis indicated that these genes encode a protein of unknown function plus a putative thymidine diphospho-4-keto-6-deoxyglucose-3(5)-epimerase and thymidine diphospho-4-ketodeoxyhexulose reductase, respectively. Inactivation of each of the three genes by gene disruption and replacement in the wild-type strain demonstrated that all of them are required for daunosamine biosynthesis.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9209071      PMCID： PMC179277          DOI： 10.1128/jb.179.13.4446-4450.1997

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

Review 1.  Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli.

Authors:  P N Black; C C DiRusso
Journal:  Biochim Biophys Acta       Date:  1994-01-03

2.  Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.

Authors:  H Krügel; G Schumann; F Hänel; G Fiedler
Journal:  Mol Gen Genet       Date:  1993-10

3.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Authors:  M Bierman; R Logan; K O'Brien; E T Seno; R N Rao; B E Schoner
Journal:  Gene       Date:  1992-07-01       Impact factor: 3.688

4.  Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.

Authors:  C Scotti; C R Hutchinson
Journal:  J Bacteriol       Date:  1996-12       Impact factor: 3.490

5.  Structure and transcriptional regulation of the Escherichia coli adaptive response gene aidB.

Authors:  P Landini; L I Hajec; M R Volkert
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

6.  Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri.

Authors:  D F Macpherson; P A Manning; R Morona
Journal:  Mol Microbiol       Date:  1994-01       Impact factor: 3.501

Review 7.  Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

Authors:  H W Liu; J S Thorson
Journal:  Annu Rev Microbiol       Date:  1994       Impact factor: 15.500

8.  Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.

Authors:  J S Thorson; S F Lo; O Ploux; X He; H W Liu
Journal:  J Bacteriol       Date:  1994-09       Impact factor: 3.490

9.  Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus.

Authors:  S L Otten; J Ferguson; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

10.  Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius.

Authors:  K Madduri; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490
View more
  7 in total

Review 1.  Biosynthesis of polyketides in heterologous hosts.

Authors:  B A Pfeifer; C Khosla
Journal:  Microbiol Mol Biol Rev       Date:  2001-03       Impact factor: 11.056

2.  Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

Authors:  I Aguirrezabalaga; C Olano; N Allende; L Rodriguez; A F Braña; C Méndez; J A Salas
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

3.  Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification.

Authors:  Katelyn V Brown; Benjamin Nji Wandi; Mikko Metsä-Ketelä; S Eric Nybo
Journal:  J Org Chem       Date:  2020-09-22       Impact factor: 4.354

4.  Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells.

Authors:  Slavko Komarnytsky; Debora Esposito; Alexander Poulev; Ilya Raskin
Journal:  J Cell Physiol       Date:  2013-05       Impact factor: 6.384

5.  Chemobiosynthesis of new antimalarial macrolides.

Authors:  Christopher D Goodman; Mariana Useglio; Salvador Peirú; Guillermo R Labadie; Geoffrey I McFadden; Eduardo Rodríguez; Hugo Gramajo
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

6.  Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model.

Authors:  Slavko Komarnytsky; Debora Esposito; Thirumurugan Rathinasabapathy; Alexander Poulev; Ilya Raskin
Journal:  J Agric Food Chem       Date:  2013-02-17       Impact factor: 5.279

Review 7.  Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Microb Biotechnol       Date:  2010-11-18       Impact factor: 5.813
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.