Literature DB >> 7591094

Reduced virulence of Candida albicans mutants affected in multidrug resistance.

J M Becker1, L K Henry, W Jiang, Y Koltin.   

Abstract

Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.

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Year:  1995        PMID： 7591094      PMCID： PMC173643          DOI： 10.1128/iai.63.11.4515-4518.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

Review 1.  ABC transporters: from microorganisms to man.

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Journal:  Annu Rev Cell Biol       Date:  1992

2.  Pathogenicity of Candida albicans auxotrophic mutants in experimental infections.

Authors:  D R Kirsch; R R Whitney
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

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Authors:  S Sternberg
Journal:  Science       Date:  1994-12-09       Impact factor: 47.728

4.  Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate.

Authors:  M E Fling; J Kopf; A Tamarkin; J A Gorman; H A Smith; Y Koltin
Journal:  Mol Gen Genet       Date:  1991-06

5.  Allelism of SNQ1 and ATR1, genes of the yeast Saccharomyces cerevisiae required for controlling sensitivity to 4-nitroquinoline-N-oxide and aminotriazole.

Authors:  P Gömpel-Klein; M Brendel
Journal:  Curr Genet       Date:  1990-07       Impact factor: 3.886

Review 6.  A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.

Authors:  M D Marger; M H Saier
Journal:  Trends Biochem Sci       Date:  1993-01       Impact factor: 13.807

7.  ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.

Authors:  S Kanazawa; M Driscoll; K Struhl
Journal:  Mol Cell Biol       Date:  1988-02       Impact factor: 4.272

8.  Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.

Authors:  M Raymond; P Gros; M Whiteway; D Y Thomas
Journal:  Science       Date:  1992-04-10       Impact factor: 47.728

9.  Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.

Authors:  K Kuchler; J Thorner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

10.  Multidrug resistance in Candida albicans: disruption of the BENr gene.

Authors:  M Goldway; D Teff; R Schmidt; A B Oppenheim; Y Koltin
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191
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  23 in total

Review 1.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

Review 2.  Fungal virulence genes as targets for antifungal chemotherapy.

Authors:  J R Perfect
Journal:  Antimicrob Agents Chemother       Date:  1996-07       Impact factor: 5.191

Review 3.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

4.  Comparative resistance of Candida albicans clinical isolates to fluconazole and itraconazole in vitro and in vivo in a murine model.

Authors:  A Valentin; R Le Guennec; E Rodriguez; J Reynes; M Mallie; J M Bastide
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

Review 5.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

6.  Enhanced extracellular production of aspartyl proteinase, a virulence factor, by Candida albicans isolates following growth in subinhibitory concentrations of fluconazole.

Authors:  T Wu; K Wright; S F Hurst; C J Morrison
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

7.  Impact of multidrug-resistant Pseudomonas aeruginosa bacteremia on patient outcomes.

Authors:  Vincent H Tam; Cary A Rogers; Kai-Tai Chang; Jaye S Weston; Juan-Pablo Caeiro; Kevin W Garey
Journal:  Antimicrob Agents Chemother       Date:  2010-06-28       Impact factor: 5.191

8.  Relationship between susceptibility of Candida spp. isolates to amphotericin B and death or survival of patients with candidemia episodes.

Authors:  Sydney Hartz Alves; Everton Boff; Patricia Pozzatti; Liliane A Scheid; Erico de Loreto; Loiva T Ottoneli Oliveira; Valério Aquino; Luiz Carlos Severo; Janio Morais Santurio
Journal:  Mycopathologia       Date:  2008-09-26       Impact factor: 2.574

9.  Fluconazole versus Candida albicans: a complex relationship.

Authors:  J R Graybill; E Montalbo; W R Kirkpatrick; M F Luther; S G Revankar; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

Review 10.  Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches.

Authors:  B D Alexander; J R Perfect
Journal:  Drugs       Date:  1997-11       Impact factor: 9.546
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