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Literature DB >> 7585475

Anticancer and antioxidant activity of synthetic chalcones and related compounds.

R J Anto¹, K Sukumaran, G Kuttan, M N Rao, V Subbaraju, R Kuttan.

Abstract

Nineteen synthetic chalcones and ten structurally related compounds were investigated for their cytotoxic, tumour reducing and antioxidant activities. Methyl and hydroxy substituted chalcones were found to be cytotoxic in vitro whereas only hydroxy substituted chalcones could reduce ascites tumour in animals. Although most of the compounds analysed showed antioxidant activity, hydroxy and methyl substituted compounds were found to be the most potent antioxidants.

Entities: Chemical Disease

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Year: 1995 PMID： 7585475 DOI： 10.1016/0304-3835(95)03945-s

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

23 in total

1. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.

Authors: E C Torres-Santos; D L Moreira; M A Kaplan; M N Meirelles; B Rossi-Bergmann
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

2. Theoretical study on the antioxidant properties of 2'-hydroxychalcones: H-atom vs. electron transfer mechanism.

Authors: Yunsheng Xue; Youguang Zheng; Ling Zhang; Wenya Wu; Ding Yu; Yi Liu
Journal: J Mol Model Date: 2013-06-26 Impact factor: 1.810

3. Synthesis, electronic, and spectral properties of novel geranylated chalcone derivatives: a theoretical and experimental study.

Authors: J C Espinoza-Hicks; J M Nápoles-Duarte; G V Nevárez-Moorillón; A Camacho-Dávila; L M Rodríguez-Valdez
Journal: J Mol Model Date: 2016-10-03 Impact factor: 1.810

Anticancer and antioxidant activity of synthetic chalcones and related compounds.

1. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.

2. Theoretical study on the antioxidant properties of 2'-hydroxychalcones: H-atom vs. electron transfer mechanism.

3. Synthesis, electronic, and spectral properties of novel geranylated chalcone derivatives: a theoretical and experimental study.

4. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.

Review 5. A Comprehensive Review of Aminochalcones.

Review 6. 1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.

7. (E)-3-(4-Fluoro-phen-yl)-1-[4-(methyl-sulfan-yl)phen-yl]prop-2-en-1-one.

8. The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth.

9. The chalcone derivative (E)-1-(4-fluoro-phen-yl)-3-(4-hy-droxy-3-meth-oxy-phen-yl)prop-2-en-1-one monohydrate.

10. 4-Hydroxyhalcone effects on cisplatin-induced genotoxicity model.