Literature DB >> 7585045

Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections.

S Q Liu1, K Saijo, T Todoroki, T Ohno.   

Abstract

Human autologous tumour-specific cytotoxic T lymphocytes (CTL) were generated from peripheral blood on small formalin-fixed paraffin-embedded sections of a gastric cancer. The CTL killed live target cells at an effector/target ratio of 1 within 24 hours and showed the same target specificity as those induced on live cancer cells. The killing activity of the CTL lasted for more than four months in culture and was inhibited by antibodies against CD8 and MHC-class I. These results suggest that adoptive immunotherapy of tumours will be possible with CTL induced on a stable source of tumour antigen.

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Year:  1995        PMID： 7585045     DOI： 10.1038/nm0395-267

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  31 in total

1.  A GFP-transfected HFWT cell line, GHINK-1, as a novel target for non-RI activated natural killer cytotoxicity assay.

Authors:  Hideki Harada; Kaoru Saijo; Isamu Ishiwata; Tadao Ohno
Journal:  Hum Cell       Date:  2004-03       Impact factor: 4.174

2.  Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads.

Authors:  S Q Liu; L S Liu; T Ohno
Journal:  Cytotechnology       Date:  1998-01       Impact factor: 2.058

3.  Induction of auto-logous human cytotoxic T lymphocytes (CTL) from peripheral blood against tumor cells.

Authors:  T Ohno
Journal:  Cytotechnology       Date:  1997-01       Impact factor: 2.058

4.  Recycled addition of CD4+ T cell-rich population for induction of human autologous cytotoxic T lymphocytes: A practically efficient method.

Authors:  K Saijo; H Tsurushima; K Tsuboi; T Nose; A Oki; T Ohno
Journal:  Cytotechnology       Date:  2000-10       Impact factor: 2.058

5.  Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.

Authors:  Edith J Mensah-Osman; Dafydd G Thomas; Michelle M Tabb; Jose M Larios; Dennis P Hughes; Thomas J Giordano; Michelle L Lizyness; James M Rae; Bruce Blumberg; Paul F Hollenberg; Laurence H Baker
Journal:  Cancer       Date:  2007-03-01       Impact factor: 6.860

6.  Telomere dysfunction alters the chemotherapeutic profile of transformed cells.

Authors:  K H Lee; K L Rudolph; Y J Ju; R A Greenberg; L Cannizzaro; L Chin; S R Weiler; R A DePinho
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

7.  Tumor vaccine against recurrence of hepatocellular carcinoma.

Authors:  Bao-Gang Peng; Li-Jiang Liang; Qiang He; Ming Kuang; Jia-Ming Lia; Ming-De Lu; Jie-Fu Huang
Journal:  World J Gastroenterol       Date:  2005-02-07       Impact factor: 5.742

8.  Activation of human T lymphocytes by ganglioside-containing liposomes.

Authors:  K Yanagihara; E Kato; S Hitomi; J Sunamoto; H Wada
Journal:  Glycoconj J       Date:  1999-01       Impact factor: 2.916

9.  Targeted tumor cell death induced by autologous tumor-specific T lymphocyte recognition of wild-type p53-derived peptides.

Authors:  Hideo Tsurushima; Yoshihiko Yoshii; Kam W Leong; Tadao Ohno
Journal:  J Neurooncol       Date:  2006-01       Impact factor: 4.130

10.  Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma.

Authors:  Dietmar Abraham; Karin Zins; Mouldy Sioud; Trevor Lucas; Romana Schäfer; E Richard Stanley; Seyedhossein Aharinejad
Journal:  Int J Cancer       Date:  2010-03-15       Impact factor: 7.396
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