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Literature DB >> 7584151

V-D-J rearrangements at the T cell receptor delta locus in mouse thymocytes of the alpha beta lineage.

P B Nakajima¹, J P Menetski, D B Roth, M Gellert, M J Bosma.

Abstract

The T cell receptor (TCR) delta locus lies within the TCR alpha locus and is excised from the chromosome by V alpha-J alpha rearrangement. We show here that delta sequences persist in a large fraction of the DNA from mature CD4+CD8- alpha beta+ mouse thymocytes. Virtually all delta loci in these cells are rearranged and present in extrachromosomal DNA. In immature alpha beta lineage thymocytes (CD3-/loCD4+CD8+) and in CD4+CD8- alpha beta+ thymocytes expressing a transgene-encoded alpha beta receptor, rearranged delta genes are present both in chromosomal and extrachromosomal DNA. Thus, contrary to earlier proposals, commitment to the alpha beta lineage does not require recombinational silencing of the delta locus or its deletion by a site-specific mechanism prior to V alpha-J alpha rearrangement.

Entities: Gene Species

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Year: 1995 PMID： 7584151 DOI： 10.1016/1074-7613(95)90132-9

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

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Cited

13 in total

1. Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements.

Authors: J L Chain; M L Joachims; S W Hooker; A B Laurent; C K Knott-Craig; L F Thompson
Journal: J Immunol Methods Date: 2005-03-18 Impact factor: 2.303

2. An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.

Authors: X P Zhong; M S Krangel
Journal: Proc Natl Acad Sci U S A Date: 1997-05-13 Impact factor: 11.205

3. Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.

Authors: Zachary M Carico; Kingshuk Roy Choudhury; Baojun Zhang; Yuan Zhuang; Michael S Krangel
Journal: Cell Rep Date: 2017-06-06 Impact factor: 9.423

4. Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus.

Authors: F Livák; D G Schatz
Journal: Proc Natl Acad Sci U S A Date: 1998-05-12 Impact factor: 11.205

5. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.

Authors: Shixue Shen; Tim Manser
Journal: J Immunol Date: 2011-11-30 Impact factor: 5.422

V-D-J rearrangements at the T cell receptor delta locus in mouse thymocytes of the alpha beta lineage.

1. Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements.

2. An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.

3. Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.

4. Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus.

5. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.

6. Cryptic signals and the fidelity of V(D)J joining.

7. Characterization of excised DNA intermediates associated with V(D)J recombination at the T-cell receptor delta locus.

Review 8. Mechanics of T cell receptor gene rearrangement.

9. Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer.

10. The common cytokine receptor gamma chain controls survival of gamma/delta T cells.