Literature DB >> 7582534

Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin.

P Ferdinandy1, Z Szilvássy, T Csont, C Csonka, E Nagy, M Koltai, L Dux.   

Abstract

We investigated whether nitroglycerin (NTG) was able to produce an anti-ischaemic effect in isolated working hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non-tolerant rats were subjected to 10 min coronary occlusion in the presence of 10(-7) M NTG and/or its solvent. NTG alleviated ischaemia-induced deterioration of cardiac function and decreased lactate dehydrogenase release whilst having no effect on coronary flow nor the area of the ischaemic zone both in hearts isolated from NTG-tolerant and non-tolerant rats. The magnitude of the effect was similar in the two groups. These results suggest that the anti-ischaemic effect of NTG involves direct myocardial mechanisms independent of its vascular action and that vascular tolerance to NTG does not affect this direct protective action.

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Year:  1995        PMID： 7582534      PMCID： PMC1908768          DOI： 10.1111/j.1476-5381.1995.tb15014.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Reversal or nitroglycerin tolerance by the cGMP phosphodiesterase inhibitor zaprinast.

Authors:  P J Silver; E D Pagani; L de Garavilla; G S Van Aller; M L Volberg; P F Pratt; R A Buchholz
Journal:  Eur J Pharmacol       Date:  1991-06-18       Impact factor: 4.432

2.  Ischaemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: implications for mechanisms of initiation and maintenance of ventricular fibrillation.

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4.  Myocardial relaxant effect of exogenous nitric oxide in isolated ejecting hearts.

Authors:  R Grocott-Mason; S Fort; M J Lewis; A M Shah
Journal:  Am J Physiol       Date:  1994-05

Review 5.  Nitrates in different vascular beds, nitrate tolerance, and interactions with endothelial function.

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6.  NO donor SIN-1 protects against reoxygenation-induced cardiomyocyte injury by a dual action.

Authors:  K D Schlüter; M Weber; E Schraven; H M Piper
Journal:  Am J Physiol       Date:  1994-10

7.  Effects of cysteine and nitroglycerin on bovine heart guanylate cyclase and on tissue cyclic GMP and lactate of rat atria.

Authors:  K Laustiola; P Vuorinen; H Vapaatalo; T Metsä-Ketelä
Journal:  Eur J Pharmacol       Date:  1983-07-22       Impact factor: 4.432

8.  Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.

Authors:  P Ferdinandy; Z Szilvássy; M Koltai; L Dux
Journal:  J Cardiovasc Pharmacol       Date:  1995-01       Impact factor: 3.105

9.  Pacing-induced ventricular fibrillation leading to oxygen free radical formation in aerobically perfused rat hearts.

Authors:  P Ferdinandy; D K Das; A Tosaki
Journal:  J Mol Cell Cardiol       Date:  1993-06       Impact factor: 5.000

10.  Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin.

Authors:  Z Szilvassy; P Ferdinandy; P Bor; I Jakab; J Szilvassy; I Nagy; J Lonovics; M Koltai
Journal:  Br J Pharmacol       Date:  1994-08       Impact factor: 8.739
  10 in total
  6 in total

1.  Deficiency in myocardial NO biosignalling after cardioplegic arrest: mechanisms and contribution to post-storage mechanical dysfunction.

Authors:  C Rach; M Gandhi; J Docherty; B A Finegan; A S Clanachan
Journal:  Br J Pharmacol       Date:  1999-10       Impact factor: 8.739

2.  Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats: a cyclic GMP-independent activation of KATP.

Authors:  T Csont; Z Szilvássy; F Fülöp; S Nedeianu; T Páli; A Tosaki; L Dux; P Ferdinandy
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

3.  Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide.

Authors:  P Ferdinandy; C Csonka; T Csont; Z Szilvássy; L Dux
Journal:  Mol Cell Biochem       Date:  1998-09       Impact factor: 3.396

4.  The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.

Authors:  Márta Sárközy; Gergő Szűcs; Márton Pipicz; Ágnes Zvara; Katalin Éder; Veronika Fekete; Csilla Szűcs; Judit Bárkányi; Csaba Csonka; László G Puskás; Csaba Kónya; Péter Ferdinandy; Tamás Csont
Journal:  Cardiovasc Diabetol       Date:  2015-06-28       Impact factor: 9.951

5.  Adverse Effects on β-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function.

Authors:  Rolf Schreckenberg; Péter Bencsik; Martin Weber; Yaser Abdallah; Csaba Csonka; Kamilla Gömöri; Krisztina Kiss; János Pálóczi; Judit Pipis; Márta Sárközy; Péter Ferdinandy; Rainer Schulz; Klaus-Dieter Schlüter
Journal:  J Am Heart Assoc       Date:  2017-12-22       Impact factor: 5.501

6.  Effect of calcitonin gene-related peptide antagonist on the cardiovascular events, mortality, and prostaglandin E2 production by nitrate-induced tolerant rats with acute myocardial infarction.

Authors:  Tamar Kezeli; Tamari Rukhadze; Nikoloz Gongadze; Galina Sukoyan; Nino Dolidze; Mariam Chipashvili; Makrine Mirziashvili
Journal:  EPMA J       Date:  2016-03-08       Impact factor: 6.543
  6 in total

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