Literature DB >> 757961

Quantitation of dexamethasone in biological fluids using high-performance liquid chromatography.

S E Tsuei, J J Ashley, R G Moore, W G McBride.   

Abstract

A sensitive and specific method for the quantitation of dexamethasone in plasma and urine is described. The specificity of the method is obtained using adsoprtion chromatography on a high-performance liquid chromatograph. The dexamethasone is detected with a variable-wavelength UV detector. An internal standard technique is used for quantitation of dexamethasone with a minimum sensitivity of 15 ng. Preliminary results of the application of the method to pharmacokinetic studies of dexamethasone in humans are reported.

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Year:  1978        PMID： 757961     DOI： 10.1016/s0378-4347(00)81341-9

Source DB:  PubMed          Journal:  J Chromatogr


  7 in total

1.  A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep.

Authors:  J B Derks; D A Giussani; S L Jenkins; R A Wentworth; G H Visser; J F Padbury; P W Nathanielsz
Journal:  J Physiol       Date:  1997-02-15       Impact factor: 5.182

Review 2.  Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review.

Authors:  J G Gambertoglio; W J Amend; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1980-02

3.  Effect of dose size on the pharmacokinetics of intravenous hydrocortisone during endogenous hydrocortisone suppression.

Authors:  R D Toothaker; P G Welling
Journal:  J Pharmacokinet Biopharm       Date:  1982-04

4.  Disposition of synethetic glucocorticoids. I. Pharmacokinetics of dexamethasone in healthy adults.

Authors:  S E Tsuei; R G Moore; J J Ashley; W G McBride
Journal:  J Pharmacokinet Biopharm       Date:  1979-06

5.  Pharmacokinetics of betamethasone in healthy adults after intravenous administration.

Authors:  M C Petersen; R L Nation; W G McBride; J J Ashley; R G Moore
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

6.  Disposition of betamethasone in parturient women after intravenous administration.

Authors:  M C Petersen; C B Collier; J J Ashley; W G McBride; R L Nation
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

7.  The placental transfer of betamethasone.

Authors:  M C Petersen; R L Nation; J J Ashley; W G McBride
Journal:  Eur J Clin Pharmacol       Date:  1980-10       Impact factor: 2.953
  7 in total

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