Literature DB >> 7439243

The placental transfer of betamethasone.

M C Petersen, R L Nation, J J Ashley, W G McBride.   

Abstract

The plasma concentrations of betamethasone in a maternal peripheral vein (mv) and in the umbilical vein (uv) were measured at delivery in eleven patients after the administration of betamethasone phosphate equivalent to 8 mg betamethasone. Betamethasone concentrations were measured in plasma using a specific and sensitive HPLC assay. The time interval between the last dose and delivery ranged from 56 min to 800 min and over this time period the mean plasma concentration ratio Cuv/Cmv was 0.28 +/- 0.04 (SD) and exhibited no time dependence.

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Year:  1980        PMID： 7439243     DOI： 10.1007/bf00563006

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  12 in total

1.  Prevention of the respiratory distress syndrome in premature infants by antepartum glucocorticoid therapy.

Authors:  E Caspi; P Schreyer; Z Weinraub; R Reif; I Levi; G Mundel
Journal:  Br J Obstet Gynaecol       Date:  1976-03

2.  [Prevention of the respiratory distress syndrome of the newborn. Value of antepartum treatment with glucocorticoids].

Authors:  P Fargier; B Salle; J C Gagnaire; P Arnaud; P Magnin
Journal:  Nouv Presse Med       Date:  1974-06-22

3.  A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

Authors:  G C Liggins; R N Howie
Journal:  Pediatrics       Date:  1972-10       Impact factor: 7.124

4.  Induction of choline phosphotransferase and lecithin synthesis in the fetal lung by corticosteroids.

Authors:  P M Farrell; R D Zachman
Journal:  Science       Date:  1973-01-19       Impact factor: 47.728

5.  Quantitation of dexamethasone in biological fluids using high-performance liquid chromatography.

Authors:  S E Tsuei; J J Ashley; R G Moore; W G McBride
Journal:  J Chromatogr       Date:  1978-03-01

6.  Prevention of the respiratory distress syndrome (RDS) by antepartum glucocorticoid (betamethasone) therapy combined with phenobarbitone and ritodrine.

Authors:  M Osler; O Faerø; B Friis-Hansen; D Trolle
Journal:  Dan Med Bull       Date:  1978-12

7.  Glucocorticoid levels in maternal and cord serum after prenatal betamethasone therapy to prevent respiratory distress syndrome.

Authors:  P L Ballard; P Granberg; R A Ballard
Journal:  J Clin Invest       Date:  1975-12       Impact factor: 14.808

8.  Cytoplasmic receptor for glucocorticoids in lung of the human fetus and neonate.

Authors:  P L Ballard; R A Ballard
Journal:  J Clin Invest       Date:  1974-02       Impact factor: 14.808

9.  Prenatal administration of betamethasone for prevention of respiratory distress syndrome.

Authors:  R A Ballard; P L Ballard; J P Granberg; S Sniderman
Journal:  J Pediatr       Date:  1979-01       Impact factor: 4.406

10.  Placental transfer and metabolism of betamethasone in human pregnancy.

Authors:  A B Anderson; G Gennser; J Y Jeremy; S Ohrlander; L Sayers; A C Turnbull
Journal:  Obstet Gynecol       Date:  1977-04       Impact factor: 7.661
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  10 in total

1.  Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.

Authors:  Matthias Schwab; Turhan Coksaygan; Mahesh N Samtani; William J Jusko; Peter W Nathanielsz
Journal:  Obstet Gynecol       Date:  2006-09       Impact factor: 7.661

2.  A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep.

Authors:  J B Derks; D A Giussani; S L Jenkins; R A Wentworth; G H Visser; J F Padbury; P W Nathanielsz
Journal:  J Physiol       Date:  1997-02-15       Impact factor: 5.182

Review 3.  The significance of plasma protein binding on the fetal/maternal distribution of drugs at steady-state.

Authors:  M D Hill; F P Abramson
Journal:  Clin Pharmacokinet       Date:  1988-03       Impact factor: 6.447

4.  Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats.

Authors:  Mahesh N Samtani; Matthias Schwab; Peter W Nathanielsz; William J Jusko
Journal:  Pharm Res       Date:  2004-12       Impact factor: 4.200

Review 5.  Placental transfer of drugs administered to the mother.

Authors:  G M Pacifici; R Nottoli
Journal:  Clin Pharmacokinet       Date:  1995-03       Impact factor: 6.447

6.  Disposition of betamethasone in parturient women after intravenous administration.

Authors:  M C Petersen; C B Collier; J J Ashley; W G McBride; R L Nation
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

7.  Disposition of betamethasone in parturient women after intramuscular administration.

Authors:  M C Petersen; J J Ashley; W G McBride; R L Nation
Journal:  Br J Clin Pharmacol       Date:  1984-09       Impact factor: 4.335

Review 8.  Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019.

Authors:  Margaux Louchet; Jeanne Sibiude; Gilles Peytavin; Olivier Picone; Jean-Marc Tréluyer; Laurent Mandelbrot
Journal:  Am J Obstet Gynecol MFM       Date:  2020-06-22

9.  Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system.

Authors:  Noor E W D Teulings; Tessa A C Garrud; Youguo Niu; Katie L Skeffington; Christian Beck; Nozomi Itani; Fiona G Conlon; Kimberley J Botting; Lisa M Nicholas; Thomas J Ashmore; Heather L Blackmore; Wen Tong; Emily J Camm; Jan B Derks; Angela Logan; Michael P Murphy; Susan E Ozanne; Dino A Giussani
Journal:  FASEB J       Date:  2020-06-05       Impact factor: 5.834

10.  Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation.

Authors:  Olena Anoshchenko; Flavia Storelli; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2021-08-23       Impact factor: 3.922
  10 in total

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