Literature DB >> 7579511

Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: an immunohistochemical study.

B Têtu1, J Brisson, J Landry, J Huot.   

Abstract

Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986. The follow-up ranged from 2.5 to 10.5 years. A polyclonal antibody (Hu27, dilution: 1/200) was used. A positive cytoplasmic staining was obtained in 383 cases (43%). No difference in distant metastasis-free survival (DMFS) or overall survival (OS) was noted between cases with positive or negative immunostaining. This study suggests that HSP-27 expression is not predictive of the outcome in node-positive breast cancer.

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Year:  1995        PMID： 7579511     DOI： 10.1007/BF00690189

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  14 in total

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4.  Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

Authors:  D R Ciocca; S A Fuqua; S Lock-Lim; D O Toft; W J Welch; W L McGuire
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5.  Pathologic findings from the National Surgical Adjuvant Project for Breast Cancers (protocol no. 4). X. Discriminants for tenth year treatment failure.

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Journal:  J Natl Cancer Inst       Date:  1991-02-06       Impact factor: 13.506

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  7 in total

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3.  The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.

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Review 5.  The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health.

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7.  Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma.

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  7 in total

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