Literature DB >> 7577478

A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.

R V Iaffaioli1, A Tortoriello, G Facchini, M Santangelo, G De Sena, G Gesue, L Bucci, G Scaramellino, E Anastasio, A Finizio.   

Abstract

Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation.

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Year:  1995        PMID: 7577478      PMCID: PMC2033957          DOI: 10.1038/bjc.1995.496

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  18 in total

1.  Goals of palliative cancer therapy.

Authors:  F Porzsolt; I Tannock
Journal:  J Clin Oncol       Date:  1993-02       Impact factor: 44.544

2.  Experimental antitumor activity of Navelbine.

Authors:  S Cros; M Wright; M Morimoto; H Lataste; J P Couzinier; A Krikorian
Journal:  Semin Oncol       Date:  1989-04       Impact factor: 4.929

Review 3.  The development of biological therapies for breast cancer.

Authors:  M E Lippman
Journal:  Science       Date:  1993-01-29       Impact factor: 47.728

4.  Phase II trial of weekly intravenous vinorelbine in first-line advanced breast cancer chemotherapy.

Authors:  P Fumoleau; F M Delgado; T Delozier; A Monnier; M A Gil Delgado; P Kerbrat; E Garcia-Giralt; R Keiling; M Namer; M T Closon
Journal:  J Clin Oncol       Date:  1993-07       Impact factor: 44.544

5.  Phase II evaluation of carboplatin and VP-16 for patients with metastatic breast cancer and only one prior chemotherapy regimen.

Authors:  L J Barker; S E Jones; M A Savin; R G Mennel
Journal:  Cancer       Date:  1993-08-01       Impact factor: 6.860

6.  Biochemical effects of Navelbine on tubulin and associated proteins.

Authors:  A Fellous; R Ohayon; T Vacassin; S Binet; H Lataste; A Krikorian; J P Couzinier; V Meininger
Journal:  Semin Oncol       Date:  1989-04       Impact factor: 4.929

7.  Carboplatin dosage: prospective evaluation of a simple formula based on renal function.

Authors:  A H Calvert; D R Newell; L A Gumbrell; S O'Reilly; M Burnell; F E Boxall; Z H Siddik; I R Judson; M E Gore; E Wiltshaw
Journal:  J Clin Oncol       Date:  1989-11       Impact factor: 44.544

8.  Carboplatin: an active drug in metastatic breast cancer.

Authors:  M Martín; E Díaz-Rubio; A Casado; P Santabárbara; J M López Vega; E Adrover; L Lenaz
Journal:  J Clin Oncol       Date:  1992-03       Impact factor: 44.544

9.  Carboplatin activity in untreated metastatic breast cancer patients--results of a phase II study.

Authors:  K Kolarić; D Vukas
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

10.  Vinorelbine (Navelbine)/carboplatin combination therapy: dose intensification with granulocyte colony-stimulating factor.

Authors:  J Crawford; M A O'Rourke
Journal:  Semin Oncol       Date:  1994-10       Impact factor: 4.929

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  3 in total

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Authors:  D de Valeriola; A Awada; J A Roy; A Di Leo; L Biganzoli; M Piccart
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2.  Biweekly vinorelbine and tegafur/uracil in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: GEICAM 2000-02 phase II study.

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Journal:  Clin Transl Oncol       Date:  2011-04       Impact factor: 3.405

3.  Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study.

Authors:  John F Kuttesch; Mark D Krailo; Timothy Madden; Mary Johansen; Archie Bleyer
Journal:  Pediatr Blood Cancer       Date:  2009-10       Impact factor: 3.167

  3 in total

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