Literature DB >> 7577466

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

P Bates1, R Fisher, A Ward, L Richardson, D J Hill, C F Graham.   

Abstract

The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse mammary gland was studied. To promote extra IGF-II expression in the mammary gland, sheep beta-lactoglobulin regulatory elements were attached to the coding regions of the mouse Igf-2 gene and injected into the pronuclei of mouse zygotes. Mammary tumours developed in each of the four independent lines of mice which expressed transgene IGF-II in the gland. Tumours from two of the lines grew after transplantation to both male and female hosts. Primary tumours contained stromal and epithelial regions, but the tumours were dominated by mammary adenocarcinoma after transplantation. The tumours expressed high levels of Igf-2 mRNA transcribed from the integrated transgenes.

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Year:  1995        PMID： 7577466      PMCID： PMC2033962          DOI： 10.1038/bjc.1995.484

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  41 in total

1.  Characterization of the gene encoding ovine beta-lactoglobulin. Similarity to the genes for retinol binding protein and other secretory proteins.

Authors:  S Ali; A J Clark
Journal:  J Mol Biol       Date:  1988-02-05       Impact factor: 5.469

2.  Body weight and cancer.

Authors:  G L Wolff
Journal:  Am J Clin Nutr       Date:  1987-01       Impact factor: 7.045

3.  Complete nucleotide sequence of the genomic ovine beta-lactoglobulin gene.

Authors:  S Harris; S Ali; S Anderson; A L Archibald; A J Clark
Journal:  Nucleic Acids Res       Date:  1988-11-11       Impact factor: 16.971

4.  Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland.

Authors:  T Sakakura; Y Nishizuka; C J Dawe
Journal:  Science       Date:  1976-12-24       Impact factor: 47.728

5.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors:  D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

6.  Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

Authors:  G K Haselbacher; J C Irminger; J Zapf; W H Ziegler; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

7.  Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome.

Authors:  G L Wolff; D W Roberts; D B Galbraith
Journal:  J Hered       Date:  1986 May-Jun       Impact factor: 2.645

8.  Alteration of morphogenesis by the v-myc oncogene in transplants of mammary gland.

Authors:  P A Edwards; J L Ward; J M Bradbury
Journal:  Oncogene       Date:  1988-04       Impact factor: 9.867

9.  Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form.

Authors:  G L Francis; F M Upton; F J Ballard; K A McNeil; J C Wallace
Journal:  Biochem J       Date:  1988-04-01       Impact factor: 3.857

10.  Insulin-like growth factors and the multiplication of Tera-2, a human teratoma-derived cell line.

Authors:  C Biddle; C H Li; P N Schofield; V E Tate; B Hopkins; W Engstrom; N S Huskisson; C F Graham
Journal:  J Cell Sci       Date:  1988-07       Impact factor: 5.285
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  42 in total

Review 1.  IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.

Authors:  D L Hadsell; S G Bonnette
Journal:  J Mammary Gland Biol Neoplasia       Date:  2000-01       Impact factor: 2.673

Review 2.  Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer.

Authors:  Deepali Sachdev; Douglas Yee
Journal:  J Mammary Gland Biol Neoplasia       Date:  2006-01       Impact factor: 2.673

Review 3.  Role of insulin-like growth factor binding proteins in mammary gland development.

Authors:  D J Flint; E Tonner; J Beattie; G J Allan
Journal:  J Mammary Gland Biol Neoplasia       Date:  2008-11-08       Impact factor: 2.673

Review 4.  Transcriptional regulation and biological significance of the insulin like growth factor II gene.

Authors:  W Engström; A Shokrai; K Otte; M Granérus; A Gessbo; P Bierke; A Madej; M Sjölund; A Ward
Journal:  Cell Prolif       Date:  1998 Oct-Dec       Impact factor: 6.831

Review 5.  Insulin-like growth factors in central nervous system tumors.

Authors:  R P Glick; T Lichtor; T G Unterman
Journal:  J Neurooncol       Date:  1997-12       Impact factor: 4.130

6.  Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.

Authors:  Detlev Biniszkiewicz; Joost Gribnau; Bernard Ramsahoye; François Gaudet; Kevin Eggan; David Humpherys; Mary-Ann Mastrangelo; Zhan Jun; Jörn Walter; Rudolf Jaenisch
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

7.  Overexpression of insulin-like growth factor II (IGFII) in ZR-75-1 human breast cancer cells: higher threshold levels of receptor (IGFIR) are required for a proliferative response than for effects on specific gene expression.

Authors:  K Abdul-Wahab; D Corcoran; A Perachiotti; P D Darbre
Journal:  Cell Prolif       Date:  1999-10       Impact factor: 6.831

Review 8.  Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.

Authors:  David L Kleinberg; Teresa L Wood; Priscilla A Furth; Adrian V Lee
Journal:  Endocr Rev       Date:  2008-12-15       Impact factor: 19.871

9.  Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1.

Authors:  Iván P Uray; Qiang Shen; Hye-Sook Seo; HeeTae Kim; William W Lamph; Reid P Bissonnette; Powel H Brown
Journal:  J Biol Chem       Date:  2008-10-28       Impact factor: 5.157

10.  PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer.

Authors:  A Belfiore; M Genua; R Malaguarnera
Journal:  PPAR Res       Date:  2009-07-07       Impact factor: 4.964
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