Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Insulin-like growth factors and the multiplication of Tera-2, a human teratoma-derived cell line.

Literature DB >> 3253292

Insulin-like growth factors and the multiplication of Tera-2, a human teratoma-derived cell line.

C Biddle¹, C H Li, P N Schofield, V E Tate, B Hopkins, W Engstrom, N S Huskisson, C F Graham.

Abstract

A human teratoma cell line (Tera-2) was grown in serum-free medium, and the population multiplication was stimulated by the addition of somatomedins/insulin-like growth factors (IGFs). Both IGF-I and IGF-II gave maximal stimulation when added daily at 10 ng ml-1. The IGFs did not substantially change the labelling index of the cells, and the IGFs appeared to exert their effect on population multiplication by increasing cell survival. Membranes isolated from Tera-2 cells displayed both type 1 and type 2 IGF receptors.

Entities: Chemical

Mesh：

Substances：

Year: 1988 PMID： 3253292 DOI： 10.1242/jcs.90.3.475

Source DB: PubMed Journal: J Cell Sci ISSN： 0021-9533 Impact factor: 5.285

Keyword Cloud
Cited

11 in total

1. IGF-II dependent autocrine growth in cell lines derived from renal tumours of childhood.

Authors: W Zumkeller; A Mahmood; R Dellow; P N Schofield
Journal: Clin Mol Pathol Date: 1995-12

Review 2. Transcriptional regulation and biological significance of the insulin like growth factor II gene.

Authors: W Engström; A Shokrai; K Otte; M Granérus; A Gessbo; P Bierke; A Madej; M Sjölund; A Ward
Journal: Cell Prolif Date: 1998 Oct-Dec Impact factor: 6.831

3. Insulin-like growth factors I and II induce cell death in Wilms's tumour cells.

Authors: M Granérus; A Johannisson; P Ekblom; W Engström
Journal: Mol Pathol Date: 2001-02

4. Insulin-like growth factor II prevents apoptosis in a human teratoma derived cell line.

Authors: M Granerus; P Bierke; W Zumkeller; J Smith; W Engström; P N Schofield
Journal: Clin Mol Pathol Date: 1995-06

5. Immunohistochemical pattern of insulin-like growth factor (IGF) I, IGF II and IGF binding proteins 1 to 6 in carcinoma in situ of the testis.

Authors: B Drescher; H Lauke; M Hartmann; M S Davidoff; W Zumkeller
Journal: Mol Pathol Date: 1997-12

Insulin-like growth factors and the multiplication of Tera-2, a human teratoma-derived cell line.

1. IGF-II dependent autocrine growth in cell lines derived from renal tumours of childhood.

Review 2. Transcriptional regulation and biological significance of the insulin like growth factor II gene.

3. Insulin-like growth factors I and II induce cell death in Wilms's tumour cells.

4. Insulin-like growth factor II prevents apoptosis in a human teratoma derived cell line.

5. Immunohistochemical pattern of insulin-like growth factor (IGF) I, IGF II and IGF binding proteins 1 to 6 in carcinoma in situ of the testis.

Review 6. Epigenetic regulation of the Igf2/H19 gene cluster.

7. Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma.

8. Expression of Insulin-like Growth Factors in a Mouse Model of Salicylate Ototoxicity.

Review 9. Insulin-like growth factors and cancer.

10. Tumour suppression associated with expression of human insulin-like growth factor II.