Literature DB >> 7572883

Site dependence of postmortem blood methadone concentrations.

B Levine1, S C Wu, A Dixon, J E Smialek.   

Abstract

A case investigated by the Office of the Chief Medical Examiner, State of Maryland, identified methadone at a heart blood concentration of 2.4 mg/L and a subclavian blood concentration of 0.8 mg/L. Due to these discrepant results, a study was undertaken to determine whether such inconsistencies occurred in other methadone cases. Of the 15 cases studied, only four had heart blood and alternate blood concentrations within 20% of one another. In only 53% of the cases were variations of < 60% observed. The data failed to show a trend where one site was consistently higher or lower than the other site.

Entities:  

Mesh:

Substances:

Year:  1995        PMID: 7572883     DOI: 10.1097/00000433-199506000-00002

Source DB:  PubMed          Journal:  Am J Forensic Med Pathol        ISSN: 0195-7910            Impact factor:   0.921


  10 in total

1.  Toxicology and pathology of deaths related to methadone: retrospective review.

Authors:  S B Karch; B G Stephens
Journal:  West J Med       Date:  2000-01

Review 2.  Liver and peripheral blood concentration ratio (L/P) as a marker of postmortem drug redistribution: a literature review.

Authors:  Iain M McIntyre
Journal:  Forensic Sci Med Pathol       Date:  2013-11-07       Impact factor: 2.007

3.  Intravenous methadone application as a serious risk factor for an overdose death: methadone-related fatalities in Hamburg from 2007 to 2012.

Authors:  Stefanie Iwersen-Bergmann; Hilke Jungen; Hilke Andresen-Streichert; Alexander Müller; Sally Elakkary; Klaus Püschel; Axel Heinemann
Journal:  Int J Legal Med       Date:  2014-05-25       Impact factor: 2.686

4.  Methadone deaths: a toxicological analysis.

Authors:  C M Milroy; A R Forrest
Journal:  J Clin Pathol       Date:  2000-04       Impact factor: 3.411

5.  Trends in methadone-related deaths in Zurich.

Authors:  Patrick Johannes Laberke; Christine Bartsch
Journal:  Int J Legal Med       Date:  2010-03-27       Impact factor: 2.686

6.  Fatal methadone overdose. Better understanding of body's handling of methadone is needed.

Authors:  E W Benbow; I S Roberts; A Cairns
Journal:  BMJ       Date:  1996-12-07

7.  Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).

Authors:  Wenjie Jessie Lu; Robert Bies; Landry K Kamden; Zeruesenay Desta; David A Flockhart
Journal:  Drug Metab Dispos       Date:  2010-04-21       Impact factor: 3.922

8.  Postmortem distribution pattern of morphine and morphine glucuronides in heroin overdose.

Authors:  G Skopp; R Lutz; B Ganssmann; R Mattern; R Aderjan
Journal:  Int J Legal Med       Date:  1996       Impact factor: 2.686

9.  Methadone toxicity in infants: a report of two fatalities.

Authors:  V Mistry; A J Jeffery; W Madira; C J H Padfield; G N Rutty
Journal:  Forensic Sci Med Pathol       Date:  2010-01-20       Impact factor: 2.007

10.  Methadone, Buprenorphine, Oxycodone, Fentanyl and Tramadol in Multiple Postmortem Matrices.

Authors:  Stine Marie Havig; Vigdis Vindenes; Åse Marit Leere Øiestad; Sidsel Rogde; Cecilie Hasselø Thaulow
Journal:  J Anal Toxicol       Date:  2022-07-14       Impact factor: 3.220

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.