OBJECTIVE: The aim of this study was to examine the potential of accurate image registration for detecting subtle changes in the brain. MATERIALS AND METHODS: Isotropic T1-weighted volume images were obtained in 10 normal subjects and five patients on two or more occasions (including pre- and postcontrast studies). The images were segmented and a 3D rigid body translation and rotation technique was used with sinc interpolation to precisely match the images using a chi 2-test. The registered images and the subtraction images produced from them were used to detect changes in signal intensity, sit, shape, and size of the brain. RESULTS: Small changes due to differences in orientation of the head, growth, and development as well as inhalation of oxygen and carbogen (95% O2/5% CO2) were observed in normal subjects. Changes were also observed in patients with minor head trauma, a meningioma, an astrocytoma, and multiple sclerosis. Differences due to contrast enhancement and surgery and/or anesthesia were also seen. CONCLUSION: With use of subvoxel registration, subtle changes in the brain were detected in a variety of physiological and clinical situations where differences have hitherto been difficult or impossible to detect.
OBJECTIVE: The aim of this study was to examine the potential of accurate image registration for detecting subtle changes in the brain. MATERIALS AND METHODS: Isotropic T1-weighted volume images were obtained in 10 normal subjects and five patients on two or more occasions (including pre- and postcontrast studies). The images were segmented and a 3D rigid body translation and rotation technique was used with sinc interpolation to precisely match the images using a chi 2-test. The registered images and the subtraction images produced from them were used to detect changes in signal intensity, sit, shape, and size of the brain. RESULTS: Small changes due to differences in orientation of the head, growth, and development as well as inhalation of oxygen and carbogen (95% O2/5% CO2) were observed in normal subjects. Changes were also observed in patients with minor head trauma, a meningioma, an astrocytoma, and multiple sclerosis. Differences due to contrast enhancement and surgery and/or anesthesia were also seen. CONCLUSION: With use of subvoxel registration, subtle changes in the brain were detected in a variety of physiological and clinical situations where differences have hitherto been difficult or impossible to detect.
Authors: Sungwon Chung; Daniel Pelletier; Michael Sdika; Ying Lu; Jeffrey I Berman; Roland G Henry Journal: Neuroimage Date: 2007-11-07 Impact factor: 6.556
Authors: Bradley J Erickson; Jayawant Mandrekar; Liqin Wang; Julia W Patriarche; Brian J Bartholmai; Christropher P Wood; E Paul Lindell; Anne-Marie Sykes; Gordon F Harms; Rebecca M Lindell; Katherine Andirole Journal: J Digit Imaging Date: 2007-06 Impact factor: 4.056
Authors: Daniel Forsberg; Amit Gupta; Christopher Mills; Brett MacAdam; Beverly Rosipko; Barbara A Bangert; Michael D Coffey; Christos Kosmas; Jeffrey L Sunshine Journal: Int J Comput Assist Radiol Surg Date: 2016-11-26 Impact factor: 2.924