Literature DB >> 7557969

Improved carrier testing for multiple endocrine neoplasia, type 1, using new microsatellite-type DNA markers.

S Kytölä1, J Leisti, R Winqvist, P Salmela.   

Abstract

Familial multiple endocrine neoplasia, type 1 (FMEN1), is an autosomal dominant trait generated by hyperfunction of various endocrine glands. The gene for MEN1 has been mapped to chromosome 11q13 by genetic linkage and deletion mapping in tumors. Eight Finnish families, including 46 individuals carrying the risk haplotype, have been typed for four polymorphic microsatellite DNA markers spanning the MEN1 chromosomal region. Three of the loci concerned, D11S913, D11S987, and D11S1337, displayed maximum lod scores (Zmax) 6.70, 9.88, and 2.54, respectively, with no recombinations with the disease gene, whereas a Zmax of 8.43 was obtained for D11S971 at a recombination fraction of 0.03. Our results indicate that the use of this set of markers considerably improves the diagnostic value of genotyping patients at risk of developing MEN1.

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Year:  1995        PMID： 7557969     DOI： 10.1007/bf00191805

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  17 in total

1.  A second-generation linkage map of the human genome.

Authors:  J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
Journal:  Nature       Date:  1992-10-29       Impact factor: 49.962

2.  Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.

Authors:  A E Bale; J A Norton; E L Wong; J S Fryburg; P N Maton; E H Oldfield; E Streeten; G D Aurbach; M L Brandi; E Friedman
Journal:  Cancer Res       Date:  1991-02-15       Impact factor: 12.701

Review 3.  Disease gene mapping in isolated human populations: the example of Finland.

Authors:  A de la Chapelle
Journal:  J Med Genet       Date:  1993-10       Impact factor: 6.318

4.  Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1.

Authors:  E Friedman; K Sakaguchi; A E Bale; A Falchetti; E Streeten; M B Zimering; L S Weinstein; W O McBride; Y Nakamura; M L Brandi
Journal:  N Engl J Med       Date:  1989-07-27       Impact factor: 91.245

5.  Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11.

Authors:  R V Thakker; P Bouloux; C Wooding; K Chotai; P M Broad; N K Spurr; G M Besser; J L O'Riordan
Journal:  N Engl J Med       Date:  1989-07-27       Impact factor: 91.245

6.  Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11.

Authors:  S J Bale; A E Bale; K Stewart; L Dachowski; O W McBride; T Glaser; J E Green; J J Mulvihill; M L Brandi; K Sakaguchi
Journal:  Genomics       Date:  1989-04       Impact factor: 5.736

7.  Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphisms.

Authors:  C Larsson; J Shepherd; Y Nakamura; C Blomberg; G Weber; B Werelius; N Hayward; B Teh; T Tokino; B Seizinger
Journal:  J Clin Invest       Date:  1992-04       Impact factor: 14.808

8.  Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

Authors:  M Fujimori; S A Wells; Y Nakamura
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

9.  Multiple endocrine neoplasia type 1 (MEN1) in two Asian families.

Authors:  B T Teh; S I Hii; R David; V Parameswaran; S Grimmond; M K Walters; T T Tan; D J Nancarrow; S P Chan; J Mennon
Journal:  Hum Genet       Date:  1994-11       Impact factor: 4.132

10.  Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.

Authors:  C Byström; C Larsson; C Blomberg; K Sandelin; U Falkmer; B Skogseid; K Oberg; S Werner; M Nordenskjöld
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205
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  2 in total

1.  A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

Authors:  S C Guru; S K Agarwal; P Manickam; S E Olufemi; J S Crabtree; J M Weisemann; M B Kester; Y S Kim; Y Wang; M R Emmert-Buck; L A Liotta; A M Spiegel; M S Boguski; B A Roe; F S Collins; S J Marx; L Burns; S C Chandrasekharappa
Journal:  Genome Res       Date:  1997-07       Impact factor: 9.043

2.  Genetic screening in hereditary multiple endocrine neoplasia type 1: absence of a founder effect among Japanese families.

Authors:  A Sakurai; M Katai; Y Itakura; K Nakajima; K Baba; K Hashizume
Journal:  Jpn J Cancer Res       Date:  1996-09
  2 in total

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