Literature DB >> 7556990

Role of syntaxin in mouse pancreatic beta cells.

F Martín1, F Moya, L M Gutierrez, J A Reig, B Soria.   

Abstract

The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit CA(2+)-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules.

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Year:  1995        PMID： 7556990     DOI： 10.1007/s001250050364

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  10 in total

1.  The relationship between glucose-induced K+ATP channel closure and the rise in [Ca2+]i in single mouse pancreatic beta-cells.

Authors:  M Valdeolmillos; A Nadal; D Contreras; B Soria
Journal:  J Physiol       Date:  1992-09       Impact factor: 5.182

2.  The syntaxin family of vesicular transport receptors.

Authors:  M K Bennett; J E García-Arrarás; L A Elferink; K Peterson; A M Fleming; C D Hazuka; R H Scheller
Journal:  Cell       Date:  1993-09-10       Impact factor: 41.582

3.  Isolation of synaptosomal and synaptic plasma membrane fractions.

Authors:  C W Cotman
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

4.  Neuron specific expression of a membrane protein, HPC-1: tissue distribution, and cellular and subcellular localization of immunoreactivity and mRNA.

Authors:  A Inoue; K Akagawa
Journal:  Brain Res Mol Brain Res       Date:  1993-07

5.  Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.

Authors:  C Ammälä; L Eliasson; K Bokvist; O Larsson; F M Ashcroft; P Rorsman
Journal:  J Physiol       Date:  1993-12       Impact factor: 5.182

Review 6.  A molecular description of synaptic vesicle membrane trafficking.

Authors:  M K Bennett; R H Scheller
Journal:  Annu Rev Biochem       Date:  1994       Impact factor: 23.643

7.  Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells.

Authors:  G Jacobsson; A J Bean; R H Scheller; L Juntti-Berggren; J T Deeney; P O Berggren; B Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

8.  Anti-syntaxin antibodies inhibit calcium-dependent catecholamine secretion from permeabilized chromaffin cells.

Authors:  L M Gutierrez; J L Quintanar; S Viniegra; E Salinas; F Moya; J A Reig
Journal:  Biochem Biophys Res Commun       Date:  1995-01-05       Impact factor: 3.575

9.  Characterization and gene cloning of Drosophila syntaxin 1 (Dsynt1): the fruit fly homologue of rat syntaxin 1.

Authors:  J R Cerezo; F Jiménez; F Moya
Journal:  Brain Res Mol Brain Res       Date:  1995-04

10.  A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.

Authors:  A Thomas-Reetz; J W Hell; M J During; C Walch-Solimena; R Jahn; P De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205
  10 in total
  12 in total

1.  Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells.

Authors:  S N Yang; O Larsson; R Bränström; A M Bertorello; B Leibiger; I B Leibiger; T Moede; M Köhler; B Meister; P O Berggren
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

2.  Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca(2+)- but not for guanosine 5'-[gamma-thio]triphosphate-induced secretion.

Authors:  F Martin; E Salinas; J Vazquez; B Soria; J A Reig
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

3.  The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.

Authors:  J Lang; M Fukuda; H Zhang; K Mikoshiba; C B Wollheim
Journal:  EMBO J       Date:  1997-10-01       Impact factor: 11.598

4.  SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion.

Authors:  C Gonelle-Gispert; P A Halban; H Niemann; M Palmer; S Catsicas; K Sadoul
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

5.  Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor.

Authors:  J Lang; Y Ushkaryov; A Grasso; C B Wollheim
Journal:  EMBO J       Date:  1998-02-02       Impact factor: 11.598

6.  Pancreatic islet cells: a model for calcium-dependent peptide release.

Authors:  Bernat Soria; Eva Tudurí; Alejandro González; Abdelkrim Hmadcha; Franz Martin; Angel Nadal; Ivan Quesada
Journal:  HFSP J       Date:  2010-03-30

7.  Correlation of syntaxin-1 and SNAP-25 clusters with docking and fusion of insulin granules analysed by total internal reflection fluorescence microscopy.

Authors:  M Ohara-Imaizumi; C Nishiwaki; Y Nakamichi; T Kikuta; S Nagai; S Nagamatsu
Journal:  Diabetologia       Date:  2004-12-11       Impact factor: 10.122

8.  Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.

Authors:  H Brown; O Larsson; R Bränström; S N Yang; B Leibiger; I Leibiger; G Fried; T Moede; J T Deeney; G R Brown; G Jacobsson; C J Rhodes; J E Braun; R H Scheller; B E Corkey; P O Berggren; B Meister
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

Review 9.  Insulin granule dynamics in pancreatic beta cells.

Authors:  P Rorsman; E Renström
Journal:  Diabetologia       Date:  2003-07-17       Impact factor: 10.122

10.  Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function.

Authors:  Ivan Quesada; Juan M Rovira; Franz Martin; Enrique Roche; Angel Nadal; Bernat Soria
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-27       Impact factor: 11.205
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