Literature DB >> 7552753

The DNA-binding domain of HIV-1 integrase has an SH3-like fold.

A P Eijkelenboom1, R A Lutzke, R Boelens, R H Plasterk, R Kaptein, K Hård.   

Abstract

We have determined the solution structure of the DNA-binding domain of HIV-1 integrase by nuclear magnetic resonance spectroscopy. In solution, this carboxyterminal region of integrase forms a homodimer, consisting of two structures that closely resemble Src-homology 3 (SH3) domains. Lys 264, previously identified by mutagenesis studies to be important for DNA binding of the integrase, as well as several adjacent basic amino acids are solvent exposed. The identification of an SH3-like domain in integrase provides a new potential target for drug design.

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Year:  1995        PMID： 7552753     DOI： 10.1038/nsb0995-807

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  104 in total

Review 1.  Retroviral DNA integration.

Authors:  P Hindmarsh; J Leis
Journal:  Microbiol Mol Biol Rev       Date:  1999-12       Impact factor: 11.056

2.  Monoclonal antibodies against the minimal DNA-binding domain in the carboxyl-terminal region of human immunodeficiency virus type 1 integrase.

Authors:  T Ishikawa; N Okui; N Kobayashi; R Sakuma; T Kitamura; Y Kitamura
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

3.  Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.

Authors:  J C Chen; J Krucinski; L J Miercke; J S Finer-Moore; A H Tang; A D Leavitt; R M Stroud
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

4.  Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes.

Authors:  K Gao; S L Butler; F Bushman
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

5.  Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.

Authors:  J Y Wang; H Ling; W Yang; R Craigie
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

6.  Molecular dynamics studies on the HIV-1 integrase catalytic domain.

Authors:  R D Lins; J M Briggs; T P Straatsma; H A Carlson; J Greenwald; S Choe; J A McCammon
Journal:  Biophys J       Date:  1999-06       Impact factor: 4.033

7.  Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation.

Authors:  Ariel A Di Nardo; Dmitry M Korzhnev; Peter J Stogios; Arash Zarrine-Afsar; Lewis E Kay; Alan R Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

8.  Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

Authors:  Jacques J Kessl; Nivedita Jena; Yasuhiro Koh; Humeyra Taskent-Sezgin; Alison Slaughter; Lei Feng; Suresh de Silva; Li Wu; Stuart F J Le Grice; Alan Engelman; James R Fuchs; Mamuka Kvaratskhelia
Journal:  J Biol Chem       Date:  2012-03-21       Impact factor: 5.157

Review 9.  HIV DNA integration.

Authors:  Robert Craigie; Frederic D Bushman
Journal:  Cold Spring Harb Perspect Med       Date:  2012-07       Impact factor: 6.915

10.  A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.

Authors:  Min Li; Xuemin Chen; Huaibin Wang; Kellie A Jurado; Alan N Engelman; Robert Craigie
Journal:  J Mol Biol       Date:  2020-02-13       Impact factor: 5.469
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