Literature DB >> 7552576

Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis.

E Thomas1, J L Leroux, F Blotman, C Chavis.   

Abstract

The conversion of endogenous arachidonic acid (AA) by polymorphonuclear cells (PMN) from patients with rheumatoid arthritis (RA) was studied before (D0) and one day (D1) after antiinflammatory drug therapy. The biosynthesis of 5,15-diHETE and lipoxins (LXS), were investigated ex vivo, after PMN stimulation by ionophore A23187 without exogenous addition of 15-HETE. The eicosanoids were resolved by RP-HPLC and simultaneously detected at 246 and 302 nm respectively. Large amounts of 5,15-diHETE (50 to 400 ng/10(7) PMN) and significant levels of LXS (from 2 to 20 ng/10(7) PMN) were produced with individual differences between donors. Metabolite levels varied between patients but this work showed for the first time a linear relationship between the amounts of 5,15-diHETE and LXS. Moreover LXS production after treatment may be related to long-term clinical improvement of patients.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7552576     DOI： 10.1007/bf01782022

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  22 in total

Review 1.  Molecular mechanism of methotrexate action in inflammation.

Authors:  B N Cronstein
Journal:  Inflammation       Date:  1992-10       Impact factor: 4.092

2.  Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients.

Authors:  J W O'Callaghan; M J Forrest; P M Brooks
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

3.  Leukotriene B4 as a mediator of early and late reactions to antigen in humans: the effect of systemic glucocorticoid treatment in vivo.

Authors:  H S Freeland; U Pipkorn; R P Schleimer; R Bascom; L M Lichtenstein; R M Naclerio; S P Peters
Journal:  J Allergy Clin Immunol       Date:  1989-03       Impact factor: 10.793

4.  Enhanced arachidonic acid metabolism and human neutrophil migration in asthma.

Authors:  T Radeau; C Chavis; M Damon; F B Michel; A Crastes de Paulet; P H Godard
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  1990-10       Impact factor: 4.006

5.  Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions.

Authors:  C Edenius; J Haeggström; J A Lindgren
Journal:  Biochem Biophys Res Commun       Date:  1988-12-15       Impact factor: 3.575

6.  Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

Authors:  C N Serhan; M Hamberg; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

7.  Formation of lipoxins and leukotrienes by human alveolar macrophages incubated with 15(S)-HETE: a model for cellular cooperation between macrophages and airway epithelial cells.

Authors:  C Chavis; P Godard; A Crastes de Paulet; M Damon
Journal:  Eicosanoids       Date:  1992

8.  Effects of a single dose of methotrexate on 5- and 12-lipoxygenase products in patients with rheumatoid arthritis.

Authors:  J L Leroux; M Damon; C Chavis; A Crastes de Paulet; F Blotman
Journal:  J Rheumatol       Date:  1992-06       Impact factor: 4.666

9.  15-Hydroxy-eicosatetraenoic acid has minor anti-inflammatory properties in colitis.

Authors:  A P van Dijk; D M McCafferty; J H Wilson; F J Zijlstra
Journal:  Agents Actions       Date:  1993

10.  Efficacy of low-dose methotrexate in rheumatoid arthritis.

Authors:  M E Weinblatt; J S Coblyn; D A Fox; P A Fraser; D E Holdsworth; D N Glass; D E Trentham
Journal:  N Engl J Med       Date:  1985-03-28       Impact factor: 91.245
View more
  8 in total

1.  Lipoxins and other arachidonate derived mediators in bronchial asthma.

Authors:  C Chavis; I Vachier; P Godard; J Bousquet; P Chanez
Journal:  Thorax       Date:  2000-10       Impact factor: 9.139

Review 2.  Anti-inflammatory and proresolving lipid mediators.

Authors:  Charles N Serhan; Stephanie Yacoubian; Rong Yang
Journal:  Annu Rev Pathol       Date:  2008       Impact factor: 23.472

3.  Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.

Authors:  C B Clish; J A O'Brien; K Gronert; G L Stahl; N A Petasis; C N Serhan
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 4.  Pro- and anti-inflammatory bioactive lipids imbalance contributes to the pathobiology of autoimmune diseases.

Authors:  Undurti N Das
Journal:  Eur J Clin Nutr       Date:  2022-06-14       Impact factor: 4.016

5.  Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.

Authors:  Steven C Perry; Thomas Horn; Benjamin E Tourdot; Adriana Yamaguchi; Chakrapani Kalyanaraman; William S Conrad; Oluwayomi Akinkugbe; Michael Holinstat; Matthew P Jacobson; Theodore R Holman
Journal:  Biochemistry       Date:  2020-10-13       Impact factor: 3.162

6.  5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors.

Authors:  C Chavis; I Vachier; P Chanez; J Bousquet; P Godard
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307

7.  Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis.

Authors:  M Hachicha; M Pouliot; N A Petasis; C N Serhan
Journal:  J Exp Med       Date:  1999-06-21       Impact factor: 14.307

8.  Macrophages in synovial inflammation.

Authors:  Aisling Kennedy; Ursula Fearon; Douglas J Veale; Catherine Godson
Journal:  Front Immunol       Date:  2011-10-10       Impact factor: 7.561
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.