Literature DB >> 2849436

Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions.

C Edenius1, J Haeggström, J A Lindgren.   

Abstract

Incubation of mixed human platelet/granulocyte suspensions with ionophore A23187 led to a platelet dependent formation of several lipoxin isomers from endogenous substrate. The major metabolite coeluted with authentic lipoxin A4 (5(S), 6(R), 15(S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid) in several HPLC-systems and showed an identical UV-spectrum. Furthermore, a similar profile of lipoxins was formed in pure platelet suspensions incubated with exogenous leukotriene A4 (5(S) -5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid). The conversion of exogenous leukotriene A4 to lipoxin A4 was markedly increased in the presence of ionophore A23187.

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Year:  1988        PMID： 2849436     DOI： 10.1016/s0006-291x(88)80320-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.

Authors:  Abigail R Green; Cody Freedman; Jennyfer Tena; Benjamin E Tourdot; Benjamin Liu; Michael Holinstat; Theodore R Holman
Journal:  Biochemistry       Date:  2018-11-15       Impact factor: 3.162

2.  15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

Authors:  Steven C Perry; Chakrapani Kalyanaraman; Benjamin E Tourdot; William S Conrad; Oluwayomi Akinkugbe; John Cody Freedman; Michael Holinstat; Matthew P Jacobson; Theodore R Holman
Journal:  J Lipid Res       Date:  2020-05-13       Impact factor: 5.922

Review 3.  Lipoxins: eicosanoids carrying intra- and intercellular messages.

Authors:  C N Serhan
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

4.  Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

Authors:  C N Serhan; K A Sheppard
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

5.  Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis.

Authors:  E Thomas; J L Leroux; F Blotman; C Chavis
Journal:  Inflamm Res       Date:  1995-03       Impact factor: 4.575

6.  Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.

Authors:  Rosalina Wisastra; Petra A M Kok; Nikolaos Eleftheriadis; Matthew P Baumgartner; Carlos J Camacho; Hidde J Haisma; Frank J Dekker
Journal:  Bioorg Med Chem       Date:  2013-10-23       Impact factor: 3.641

7.  Lipoxin synthase activity of human platelet 12-lipoxygenase.

Authors:  M Romano; X S Chen; Y Takahashi; S Yamamoto; C D Funk; C N Serhan
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857

8.  Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA.

Authors:  B D Levy; S Bertram; H H Tai; E Israel; A Fischer; J M Drazen; C N Serhan
Journal:  Lipids       Date:  1993-12       Impact factor: 1.880

Review 9.  Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.

Authors:  Charles N Serhan; Nan Chiang; Thomas E Van Dyke
Journal:  Nat Rev Immunol       Date:  2008-05       Impact factor: 53.106

10.  Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.

Authors:  Robert B Zurier; Yee-Ping Sun; Kerri L George; Judith A Stebulis; Ronald G Rossetti; Ann Skulas; Erica Judge; Charles N Serhan
Journal:  FASEB J       Date:  2009-01-05       Impact factor: 5.191
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