Literature DB >> 7542803

Molecular identification of an IgE-dependent histamine-releasing factor.

S M MacDonald1, T Rafnar, J Langdon, L M Lichtenstein.   

Abstract

An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.

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Year:  1995        PMID： 7542803     DOI： 10.1126/science.7542803

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  102 in total

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