Literature DB >> 22146792

Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm.

Jayapal Manikandan1, Narasimhan Kothandaraman, Manoor Prakash Hande, Peter Natesan Pushparaj.   

Abstract

Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.

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Year:  2011        PMID： 22146792     DOI： 10.1007/s00018-011-0886-0

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  128 in total

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Authors:  Puneet S Jolly; Meryem Bektas; Ana Olivera; Claudia Gonzalez-Espinosa; Richard L Proia; Juan Rivera; Sheldon Milstien; Sarah Spiegel
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  18 in total

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5.  Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice.

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6.  IgE-Induced Mast Cell Activation Is Suppressed by Dihydromyricetin through the Inhibition of NF-κB Signaling Pathway.

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7.  Peripheral blood RNA gene expression profiling in patients with bacterial meningitis.

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Review 10.  Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today.

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