Literature DB >> 7542801

A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

A Tarakhovsky1, S B Kanner, J Hombach, J A Ledbetter, W Müller, N Killeen, K Rajewsky.   

Abstract

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7542801     DOI： 10.1126/science.7542801

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  142 in total

1.  CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.

Authors:  J J Perez-Villar; G S Whitney; M A Bowen; D H Hewgill; A A Aruffo; S B Kanner
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

2.  Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes.

Authors:  G M Doody; D D Billadeau; E Clayton; A Hutchings; R Berland; S McAdam; P J Leibson; M Turner
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

3.  CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation.

Authors:  D Kaplan; D Smith; H Meyerson; N Pecora; K Lewandowska
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-13       Impact factor: 11.205

Review 4.  CD5, an important regulator of lymphocyte selection and immune tolerance.

Authors:  Chander Raman
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

5.  Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha.

Authors:  J A Gebe; M Llewellyn; H Hoggatt; A Aruffo
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

6.  Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice.

Authors:  Stephan Kissler; Linrong Lu; Harvey Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-23       Impact factor: 11.205

7.  Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.

Authors:  Kristie M Grebe; Raedun L Clarke; Terry A Potter
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-01       Impact factor: 11.205

8.  The E47 transcription factor negatively regulates CD5 expression during thymocyte development.

Authors:  Yang Yang; Christopher H Contag; Dean Felsher; Catherine M Shachaf; Yuan Cao; Leonard A Herzenberg; Leonore A Herzenberg; James W Tung
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-04       Impact factor: 11.205

9.  Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines.

Authors:  Sunil S Raikar; Lauren C Fleischer; Robert Moot; Andrew Fedanov; Na Yoon Paik; Kristopher A Knight; Christopher B Doering; H Trent Spencer
Journal:  Oncoimmunology       Date:  2017-12-26       Impact factor: 8.110

10.  Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.

Authors:  Motoko Y Kimura; Julien Thomas; Xuguang Tai; Terry I Guinter; Miho Shinzawa; Ruth Etzensperger; Zhenhu Li; Paul Love; Toshinori Nakayama; Alfred Singer
Journal:  Nat Immunol       Date:  2016-09-26       Impact factor: 25.606
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.