| Literature DB >> 7541728 |
S Shinohara1, T Sawada, Y Nishioka, S Tohma, T Kisaki, T Inoue, K Ando, M Ikeda, H Fujii, K Ito.
Abstract
Fas antigen and Bcl-2 protein are considered to be involved in cellular homeostasis. We precisely analyzed the expression of human Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. The positivities of Fas antigen on CD4+ and CD8+ T cells increased with aging. In CD4+ T cells, the Fas-/CD45RO+ subpopulation was dominant compared with the Fas+/CD45RO- subpopulation. Conversely, in CD8+ T cells, the Fas+/CD45RO- subpopulation was dominant compared with the Fas-/CD45RO+ subpopulation. Monocytes exhibited high positivity of Fas antigen and low fluorescence intensity of Bcl-2 protein compared with T cells. These results suggest that Fas antigen acts in different processes of cellular homeostasis between CD4+ and CD8+ T cells and that expression of Fas antigen and Bcl-2 protein is involved in homeostasis of monocytes as well as lymphocytes.Entities:
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Year: 1995 PMID： 7541728 DOI： 10.1006/cimm.1995.1130
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868