Literature DB >> 10939710

Molecular steps of cell suicide: an insight into immune senescence.

S Gupta1.   

Abstract

The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mitochondrial pathways of apoptosis in general are reviewed. In particular, the role of apoptosis in T-cell immune senescence is discussed.

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Year:  2000        PMID： 10939710     DOI： 10.1023/a:1006653917314

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  136 in total

Review 1.  Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas.

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1994-08-30       Impact factor: 6.237

2.  Differential expression of Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes.

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Journal:  Cell Immunol       Date:  1995-07       Impact factor: 4.868

3.  Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

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Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

Review 4.  Transducing signals of life and death.

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Journal:  Curr Opin Cell Biol       Date:  1997-04       Impact factor: 8.382

5.  Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.

Authors:  J Yang; X Liu; K Bhalla; C N Kim; A M Ibrado; J Cai; T I Peng; D P Jones; X Wang
Journal:  Science       Date:  1997-02-21       Impact factor: 47.728

6.  Inhibition of death receptor signals by cellular FLIP.

Authors:  M Irmler; M Thome; M Hahne; P Schneider; K Hofmann; V Steiner; J L Bodmer; M Schröter; K Burns; C Mattmann; D Rimoldi; L E French; J Tschopp
Journal:  Nature       Date:  1997-07-10       Impact factor: 49.962

Review 7.  T cell differentiation and functional maturation in aging mice.

Authors:  M L Thoman; D N Ernst; M V Hobbs; W O Weigle
Journal:  Adv Exp Med Biol       Date:  1993       Impact factor: 2.622

Review 8.  Function and activation of NF-kappa B in the immune system.

Authors:  P A Baeuerle; T Henkel
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

9.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

Authors:  L H Boise; M González-García; C E Postema; L Ding; T Lindsten; L A Turka; X Mao; G Nuñez; C B Thompson
Journal:  Cell       Date:  1993-08-27       Impact factor: 41.582

10.  Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population.

Authors:  J A Timm; M L Thoman
Journal:  J Immunol       Date:  1999-01-15       Impact factor: 5.422
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  14 in total

1.  Ian4 is required for mitochondrial integrity and T cell survival.

Authors:  Malini Pandarpurkar; Leanne Wilson-Fritch; Silvia Corvera; Helle Markholst; Lars Hornum; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

Review 2.  The immune system in the elderly: activation-induced and damage-induced apoptosis.

Authors:  Lia Ginaldi; Massimo De Martinis; Daniela Monti; Claudio Franceschi
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

3.  Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors.

Authors:  Sarah M Richardson-Burns; Douglas J Kominsky; Kenneth L Tyler
Journal:  J Neurovirol       Date:  2002-10       Impact factor: 2.643

4.  Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis.

Authors:  Rama Yerramasetti; Sastry Gollapudi; Sudhir Gupta
Journal:  J Clin Immunol       Date:  2002-01       Impact factor: 8.317

5.  Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.

Authors:  Yi-Ping Lee; Wei-Ru Huang; Wun-Syuan Wu; Yuan-Hua Wu; Sheng-Yow Ho; Ying-Jan Wang; Bu-Miin Huang
Journal:  Am J Cancer Res       Date:  2022-08-15       Impact factor: 5.942

6.  Molecular basis of rifampicin-induced inhibition of anti-CD95-induced apoptosis of peripheral blood T lymphocytes: the role of CD95 ligand and FLIPs.

Authors:  Sastry Gollapudi; Suman Jaidka; Sudhir Gupta
Journal:  J Clin Immunol       Date:  2003-01       Impact factor: 8.317

Review 7.  A decision between life and death during TNF-alpha-induced signaling.

Authors:  Sudhir Gupta
Journal:  J Clin Immunol       Date:  2002-07       Impact factor: 8.317

8.  A role of fas-associated death domain (FADD) in increased apoptosis in aged humans.

Authors:  Sudhir Gupta; Choong Kim; Leman Yel; Sastry Gollapudi
Journal:  J Clin Immunol       Date:  2004-01       Impact factor: 8.317

9.  Life and death of lymphocytes: a role in immunesenescence.

Authors:  Sudhir Gupta; Houfen Su; Ruifen Bi; Sudhanshu Agrawal; Sastry Gollapudi
Journal:  Immun Ageing       Date:  2005-08-23       Impact factor: 6.400

Review 10.  Immunological outcomes of exercise in older adults.

Authors:  David S Senchina; Marian L Kohut
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458
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