Literature DB >> 7539462

Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

J L Nichol1, M M Hokom, A Hornkohl, W P Sheridan, H Ohashi, T Kato, Y S Li, T D Bartley, E Choi, J Bogenberger.   

Abstract

The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor and as a differentiation factor in human progenitor cell cultures. Megakaryocyte colony formation induced with r-HuMGDF is synergistically affected by stem cell factor but not by interleukin 3. Megakaryocytes stimulated with r-HuMGDF demonstrate progressive cytoplasmic and nuclear maturation. Measurable levels of megakaryocyte growth and development factor in serum from patients undergoing myeloablative therapy and transplantation are shown to be elaborated in response to thrombocytopenic stress. These data support the concept that megakaryocyte growth and development factor is a physiologically regulated cytokine that is capable of supporting several aspects of megakaryopoiesis.

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Year:  1995        PMID： 7539462      PMCID： PMC295986          DOI： 10.1172/JCI118005

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  37 in total

1.  Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy.

Authors:  W P Sheridan; C G Begley; C A Juttner; J Szer; L B To; D Maher; K M McGrath; G Morstyn; R M Fox
Journal:  Lancet       Date:  1992-03-14       Impact factor: 79.321

2.  Growth signal erythropoietin activates the same tyrosine kinases as interleukin 3, but activates only one tyrosine kinase as differentiation signal.

Authors:  S Kuramochi; T Chiba; H Amanuma; A Tojo; K Todokoro
Journal:  Biochem Biophys Res Commun       Date:  1991-12-31       Impact factor: 3.575

Review 3.  The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.

Authors:  D Metcalf
Journal:  Nature       Date:  1989-05-04       Impact factor: 49.962

4.  Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

Authors:  F J de Sauvage; P E Hass; S D Spencer; B E Malloy; A L Gurney; S A Spencer; W C Darbonne; W J Henzel; S C Wong; W J Kuang
Journal:  Nature       Date:  1994-06-16       Impact factor: 49.962

5.  Primary structure and functional expression of rat and human stem cell factor DNAs.

Authors:  F H Martin; S V Suggs; K E Langley; H S Lu; J Ting; K H Okino; C F Morris; I K McNiece; F W Jacobsen; E A Mendiaz
Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

6.  Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

Authors:  I K McNiece; K E Langley; K M Zsebo
Journal:  Exp Hematol       Date:  1991-03       Impact factor: 3.084

7.  Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

Authors:  I Vigon; C Florindo; S Fichelson; J L Guenet; M G Mattei; M Souyri; D Cosman; S Gisselbrecht
Journal:  Oncogene       Date:  1993-10       Impact factor: 9.867

8.  The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

Authors:  D J Kuter; D L Beeler; R D Rosenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

9.  Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

Authors:  T D Bartley; J Bogenberger; P Hunt; Y S Li; H S Lu; F Martin; M S Chang; B Samal; J L Nichol; S Swift
Journal:  Cell       Date:  1994-07-01       Impact factor: 41.582

10.  Partial purification and characterization of human megakaryocyte colony-stimulating factor (Meg-CSF).

Authors:  K Ogata; Z G Zhang; K Abe; M J Murphy
Journal:  Int J Cell Cloning       Date:  1990-01
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  6 in total

Review 1.  Historical review: megakaryopoiesis and thrombopoiesis.

Authors:  Kenneth Kaushansky
Journal:  Blood       Date:  2008-02-01       Impact factor: 22.113

Review 2.  Thrombopoietin and platelet development.

Authors:  K Kaushansky
Journal:  West J Med       Date:  1996-03

3.  Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation.

Authors:  J Goulis; T N Chau; S Jordan; A B Mehta; A Watkinson; K Rolles; A K Burroughs
Journal:  Gut       Date:  1999-05       Impact factor: 23.059

4.  Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

Authors:  A M Farese; P Hunt; L B Grab; T J MacVittie
Journal:  J Clin Invest       Date:  1996-05-01       Impact factor: 14.808

5.  Regulation of polymorphonuclear cell activation by thrombopoietin.

Authors:  M F Brizzi; E Battaglia; A Rosso; P Strippoli; G Montrucchio; G Camussi; L Pegoraro
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

6.  Thrombocytosis: a paraneoplastic syndrome in patients with hepatocellular carcinoma.

Authors:  Shinn-Jang Hwang; Jiing-Chyuan Luo; Chung-Pin Li; Cheng-Wei Chu; Jaw-Ching Wu; Chiung-Ru Lai; Jen-Huei Chiang; Gar-Yang Chau; Wing-Yiu Lui; Chun-Chung Lee; Full-Young Chang; Shou-Dong Lee
Journal:  World J Gastroenterol       Date:  2004-09-01       Impact factor: 5.742
  6 in total

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