Literature DB >> 8202154

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

F J de Sauvage1, P E Hass, S D Spencer, B E Malloy, A L Gurney, S A Spencer, W C Darbonne, W J Henzel, S C Wong, W J Kuang.   

Abstract

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

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Year:  1994        PMID： 8202154     DOI： 10.1038/369533a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  169 in total

1.  Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway.

Authors:  M C Rouyez; C Boucheron; S Gisselbrecht; I Dusanter-Fourt; F Porteu
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Authors:  Luigi J Alvarado; Heather D Huntsman; Hai Cheng; Danielle M Townsley; Thomas Winkler; Xingmin Feng; Cynthia E Dunbar; Neal S Young; Andre Larochelle
Journal:  Blood       Date:  2019-02-25       Impact factor: 22.113

3.  C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis.

Authors:  Tomas E Meijome; Jenna T B Ekwealor; R Adam Hooker; Ying-Hua Cheng; Wendy A Ciovacco; Sanjeev M Balamohan; Trishya L Srinivasan; Brahmananda R Chitteti; Pierre P Eleniste; Mark C Horowitz; Edward F Srour; Angela Bruzzaniti; Robyn K Fuchs; Melissa A Kacena
Journal:  J Cell Biochem       Date:  2015-10-06       Impact factor: 4.429

4.  The last intron of the human thrombopoietin gene enhances expression in milk of transgenic mice.

Authors:  Yan Li; Mingqian Zhou; Hongwei Zhou; Yunshan Ning
Journal:  Funct Integr Genomics       Date:  2013-11-28       Impact factor: 3.410

5.  Thrombopoietin expands hematopoietic stem cells after transplantation.

Authors:  Norma Fox; Greg Priestley; Thalia Papayannopoulou; Kenneth Kaushansky
Journal:  J Clin Invest       Date:  2002-08       Impact factor: 14.808

Review 6.  It's reticulated: the liver at the heart of atherosclerosis.

Authors:  Prabhakara R Nagareddy; Sunil K Noothi; Michelle C Flynn; Andrew J Murphy
Journal:  J Endocrinol       Date:  2018-05-02       Impact factor: 4.286

7.  ADP and inositol trisphosphate evoke oscillations of a monovalent cation conductance in rat megakaryocytes.

Authors:  J F Hussain; M P Mahaut-Smith
Journal:  J Physiol       Date:  1998-09-15       Impact factor: 5.182

8.  Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

Authors:  D C Foster; C A Sprecher; F J Grant; J M Kramer; J L Kuijper; R D Holly; T E Whitmore; M D Heipel; L A Bell; A F Ching
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

9.  Adenovirus-mediated transfer of the HST-1 (FGF4) gene induces increased levels of platelet count in vivo.

Authors:  H Sakamoto; T Ochiya; Y Sato; M Tsukamoto; H Konishi; I Saito; T Sugimura; M Terada
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.

Authors:  G Courtois; L Bénit; Y Mikaeloff; M Pauchard; M Charon; P Varlet; S Gisselbrecht
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103
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