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Literature DB >> 7534204

The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection.

L M Pinchuk¹, P S Polacino, M B Agy, S J Klaus, E A Clark.

Abstract

We investigated the role of blood dendritic cells (DCs) in transmission of HIV-1 from infected to uninfected CD4+ T cells, and the accessory molecules involved. DCs promoted transmission from infected to uninfected CD4+ cells, but DCs themselves were not infectable. DC-mediated transmission was blocked by MAb to CD4 and MHC class II, but strongly increased by MAb to CD40 on DCs or CD28 on T cells. The DC-dependent infection was inhibitable by anti-CD80 and a soluble fusion protein of the CD80 ligand, CTLA4; soluble CTLA4 immunoglobulin also blocked infection augmented by cross-linking CD40. These data suggest a linkage between CD40-CD40L and CD28-CD80 counterreceptors on DCs and T cells, and spread of HIV infection in vivo.

Entities: Disease Gene Species

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Year: 1994 PMID： 7534204 DOI： 10.1016/1074-7613(94)90083-3

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

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Cited

38 in total

1. T cell signaling mechanisms that regulate HIV-1 infection.

Authors: D Unutmaz
Journal: Immunol Res Date: 2001 Impact factor: 2.829

2. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

Authors: L J Zhou; T F Tedder
Journal: Proc Natl Acad Sci U S A Date: 1996-03-19 Impact factor: 11.205

3. Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.

Authors: A Blauvelt; H Asada; M W Saville; V Klaus-Kovtun; D J Altman; R Yarchoan; S I Katz
Journal: J Clin Invest Date: 1997-10-15 Impact factor: 14.808

4. Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.

Authors: S S Frankel; K Tenner-Racz; P Racz; B M Wenig; C H Hansen; D Heffner; A M Nelson; M Pope; R M Steinman
Journal: Am J Pathol Date: 1997-07 Impact factor: 4.307

5. Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell-T-cell mixtures without displaying subtype-specific tropism.

Authors: M Pope; S S Frankel; J R Mascola; A Trkola; F Isdell; D L Birx; D S Burke; D D Ho; J P Moore
Journal: J Virol Date: 1997-10 Impact factor: 5.103

10. Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice.

Authors: K A Green; K M Crassi; J D Laman; A Schoneveld; R R Strawbridge; T M Foy; R J Noelle; W R Green
Journal: J Virol Date: 1996-04 Impact factor: 5.103

The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection.

1. T cell signaling mechanisms that regulate HIV-1 infection.

2. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

3. Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.

4. Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.

5. Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell-T-cell mixtures without displaying subtype-specific tropism.

6. Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGN.

7. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines.

Review 8. Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.

9. SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.

10. Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice.