Literature DB >> 7530934

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.

L Guo1, N K Heinzinger, M Stevenson, L M Schopfer, J M Salhany.   

Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.

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Year:  1994        PMID： 7530934      PMCID： PMC284769          DOI： 10.1128/AAC.38.10.2483

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation.

Authors:  J P Moore; P J Klasse
Journal:  AIDS Res Hum Retroviruses       Date:  1992-04       Impact factor: 2.205

2.  Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle.

Authors:  A D Cardin; P L Smith; L Hyde; D T Blankenship; T L Bowlin; K Schroeder; K A Stauderman; D L Taylor; A S Tyms
Journal:  J Biol Chem       Date:  1991-07-15       Impact factor: 5.157

3.  The binding of pyridoxal 5'-phosphate to human serum albumin.

Authors:  M L Fonda; C Trauss; U M Guempel
Journal:  Arch Biochem Biophys       Date:  1991-07       Impact factor: 4.013

4.  Designing CD4 immunoadhesins for AIDS therapy.

Authors:  D J Capon; S M Chamow; J Mordenti; S A Marsters; T Gregory; H Mitsuya; R A Byrn; C Lucas; F M Wurm; J E Groopman
Journal:  Nature       Date:  1989-02-09       Impact factor: 49.962

5.  Fluorescence quantum yield measurements: vitamin B6 compounds.

Authors:  R F Chen
Journal:  Science       Date:  1965-12-17       Impact factor: 47.728

6.  Substrate binding in human immunodeficiency virus reverse transcriptase. An analysis of pyridoxal 5'-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain.

Authors:  A Basu; R S Tirumalai; M J Modak
Journal:  J Biol Chem       Date:  1989-05-25       Impact factor: 5.157

7.  Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

Authors:  M I Bukrinsky; N Sharova; M P Dempsey; T L Stanwick; A G Bukrinskaya; S Haggerty; M Stevenson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

Review 8.  Chemical probes for anion transporters of mammalian cell membranes.

Authors:  Z I Cabantchik; R Greger
Journal:  Am J Physiol       Date:  1992-04

9.  Metabolism of [14C]- and [32P]pyridoxal 5'-phosphate and [3H]pyridoxal administered intravenously to pigs and goats.

Authors:  S P Coburn; J D Mahuren; M S Kennedy; W E Schaltenbrand; D W Townsend
Journal:  J Nutr       Date:  1992-02       Impact factor: 4.798

10.  Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

Authors:  M Baba; R Pauwels; J Balzarini; J Arnout; J Desmyter; E De Clercq
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205
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  3 in total

Review 1.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

2.  Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.

Authors:  Quan-En Yang; Andrew G Stephen; Joseph W Adelsberger; Paula E Roberts; Weimin Zhu; Michael J Currens; Yaxiong Feng; Bruce J Crise; Robert J Gorelick; Alan R Rein; Robert J Fisher; Robert H Shoemaker; Shizuko Sei
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

3.  HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells.

Authors:  Davide Gibellini; Francesco Alviano; Anna Miserocchi; Pier Luigi Tazzari; Francesca Ricci; Alberto Clò; Silvia Morini; Marco Borderi; Pierluigi Viale; Gianandrea Pasquinelli; Pasqualepaolo Pagliaro; Gian Paolo Bagnara; Maria Carla Re
Journal:  Retrovirology       Date:  2011-05-25       Impact factor: 4.602
  3 in total

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